Mechanisms of Pregnancy Vascular Adaptations

Launched by UNIVERSITY OF WISCONSIN, MADISON · Jan 14, 2019

Keywords

ClinConnect Summary

This clinical trial, titled "Mechanisms of Pregnancy Vascular Adaptations," is focused on understanding how blood vessels change during pregnancy, particularly in women with a condition called pre-eclampsia. Researchers will collect tissue samples from the abdomen and placenta of women who are having a cesarean section, whether it’s planned or needed for medical reasons. These samples will help scientists study how a specific receptor in the blood vessels, known as AT2R, behaves in both women with pre-eclampsia and those without it.

To participate in this study, women must be between the ages of 18 and 40 and be pregnant with one baby (a singleton), at least 28 weeks along but not more than 41 weeks when they agree to join. However, if a woman has high blood pressure before her pregnancy, certain conditions affecting the baby, or other serious health issues, she may not be eligible. Participants will undergo a routine cesarean section, and they can expect to contribute to important research that could help improve understanding and treatment of vascular diseases related to pregnancy.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • female
• • Minimum age: 18
• • Maximum age: 40
• • Singleton births
• • Minimum gestational age at consent: 28 weeks, 0 days
• • Maximum gestational age at consent: 41 weeks, 0 days
• • Undergoing caesarean section, either planned or otherwise with or without trial of labor
• Exclusion Criteria:
• • Preexisting hypertension treated by antihypertensive agents during the prenatal period. This will not include treatment of severe hypertension by antihypertensive or use of magnesium sulfate after the patient is hospitalized for the diagnosis of preeclampsia.
• • Any major fetal structural anomalies or aneuploidies
• • Preexisting conditions like pre-gestational type I or type II diabetes mellitus, pre-pregnancy kidney disease with increased serum creatinine above 1.2 mg/dL, or other underlying blood vessel problems like systemic lupus erythematosus or other autoimmune conditions with evidence of pre-pregnancy proteinuria or hypertension.
• • Undergoing cesarean section for placental abruption or bleeding complications.
• • Singleton gestation not within 36 weeks, 0 days and 41 weeks, 0 days gestational age at the time of enrollment (delivery)