Can the Health Benefits of a Walking-based Exercise Programme be Enhanced by Co-ingestion of a Lipid-lowering Drug?
Launched by LIVERPOOL JOHN MOORES UNIVERSITY · Jan 17, 2019
Trial Information
Current as of October 24, 2025
Completed
Keywords
ClinConnect Summary
Study 3 investigates the hypothesis that an exercise programme of steady walking will have larger effects on insulin sensitivity and glycaemic control when combined with Acipimox intake prior to each exercise session in people with prediabetes. Thirty-four sedentary, overweight/obese people (aged 25-50 years, BMI \>28 kg.m-2) with prediabetes will be recruited using the same strategy as study 2 and split into two groups (detailed below).
Pre-intervention assessments:
Visit 1: Participants will undergo an assessment of body composition (DXA) and undertake a graded treadmill walking test to...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • BMI \>28 kg.m-2
- • Pre-diabetic
- • Not currently using any anti-diabetes medication
- • Physically inactive (performing less than two 30 min structured exercise sessions per week for the last year)
- • Not pregnant or currently breast feeding
- • Pre-menopausal
- • Not currently involved in a weight loss programme or using weight loss medication
- Exclusion Criteria:
- • Involved in regular exercise (engaged in more than 2 sessions of structured exercise of \>30 min per week)
- • Currently using anti-diabetes medication (e.g. insulin, metformin)
- • Currently using niacin/vitamin B3 supplements
- • Pregnant or breast feeding
- • Currently engaged in active weight loss programme or using weight loss medication
- • Diagnosed with chronic kidney disease
About Liverpool John Moores University
Liverpool John Moores University (LJMU) is a leading research institution in the UK, renowned for its commitment to advancing knowledge and innovation across various fields, including health and clinical sciences. With a robust infrastructure for clinical research, LJMU collaborates with healthcare professionals, industry partners, and community organizations to conduct rigorous clinical trials aimed at improving patient outcomes. The university emphasizes ethical research practices and strives to translate findings into real-world applications, fostering an environment that supports both scientific inquiry and the development of future healthcare solutions. Through its dedicated research teams and state-of-the-art facilities, LJMU continues to play a pivotal role in shaping the landscape of clinical research and education.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Liverpool, Merseyside, United Kingdom
Patients applied
Trial Officials
Jennifer s Barrett, PhD
Principal Investigator
Liverpool John Moores University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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