Fluid Challenge Infusion and Response

Launched by HUMANITAS CLINICAL AND RESEARCH CENTER · Jan 16, 2019

Keywords

ClinConnect Summary

Dedicated algorithms and protocols of anaesthetic care regarding fluid therapy are key factors to prevent perioperative hypovolaemia and/or hypervolemia, which are known to increase morbidity and length of hospital stay.

Fluid therapy is commonly used in critically ill and surgical patients to restore hemodynamics. The aim of volume expansion is to increase cardiac index and oxygen delivery and to improve tissue oxygenation. However, this occurs only in a situation of preload dependency (i.e. when the ventricle operates on the steep part of the Frank-Starling's curve). Moreover, giving flu...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Adult patients aged ≥ 18 years;
• • 2. Scheduled for elective supine neurosurgery and requiring invasive arterial monitoring;
• • 3. Glasgow coma scale 15 at recruitment
• Exclusion Criteria:
• • 1. Any recurrent cardiac arrhythmias;
• • 2. Reduced left (ejection fraction \<30%) or right (systolic peak velocity of tricuspid annular motion \<0.17 m/s) ventricular systolic function;
• • 3. Intra-operative use of vasopressors or inotropes before FC administration or between the first and the second bolus of fluids.
• • 4. Chronic use beta-blocking agents.