Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness

Launched by TECHNICAL UNIVERSITY OF MUNICH · Jan 16, 2019

Keywords

ClinConnect Summary

This clinical trial is studying a condition called Intensive Care Unit Acquired Weakness (ICUAW), which affects some patients after surgery and leads to muscle weakness. The researchers aim to understand how certain changes in blood and muscle samples can help identify what causes this weakness or if these changes can be used as markers to predict who might develop ICUAW. They will be collecting samples from patients who are expected to stay in intensive care for more than three days after their surgery.

To participate in this study, individuals need to be at least 18 years old, have undergone surgery, and require mechanical ventilation while being treated in the intensive care unit. Patients who are critically ill but not receiving active treatment for recovery will not be eligible. Participants will have blood and muscle samples taken at specific times during their hospital stay, helping doctors learn more about the metabolic changes associated with muscle weakness after surgery. This research could ultimately improve care for patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • invasive mechanically ventilated critically ill patient with expected intensive care unit stay \> 3 days
• • postoperative patient
• • ≥ 18 years old
• • American Society of Anesthesiology (ASA) classification ≥ III
• Exclusion Criteria:
• • moribund patient
• • non-curative care (comfort care)