Photomotor Reflex to Evaluate the Role of the Non-visual Effects of Light in Neurological, Psychiatric and Ophthalmological Pathologies

Launched by UNIVERSITY HOSPITAL, STRASBOURG, FRANCE · Jan 17, 2019

Keywords

ClinConnect Summary

This clinical trial is investigating how light affects our bodies beyond just helping us see. Researchers are particularly interested in how light can influence our sleep, mood, and overall behavior, especially in people with certain health conditions like sleep disorders, neurological issues, psychiatric problems, and eye diseases. The goal is to better understand these non-visual effects of light, which may help develop new treatments for these conditions.

To participate in the trial, individuals must be 18 years or older and able to provide informed consent. The study includes various groups, such as those with sleep-wake disorders, neurological or psychiatric conditions affecting sleep, and even healthy individuals. Participants can expect to learn more about how light affects their health and contribute to important research that could lead to new therapies. However, certain eye conditions like severe cataracts or age-related macular degeneration may prevent someone from joining the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Man or woman
• • Aged 18 years or older
• • Subject having signed a free and informed consent
• • Subject affiliated to a social protection scheme Arm 1 :Subjects with primary sleep-wake disorder Arm 2 : subjects presenting a neurological pathology with disorder of the controls of the wake and the sleep Arm 3 : subject presenting a psychiatric pathology pathology with disorder of the controls of the wake and the sleep Arm 4 : subject presenting an ophthalmological pathology with possible alteration of the photoreception and / or phototransduction Arm 5 : subjects with photosensitivity with regulation disorder of sleep and wake Arm 6 : healthy subject
• Exclusion Criteria:
• • Age-Related Macular Degeneration (AMD) and all maculopathies (retinopathies pigmentosa, macular involvement of diabetes)
• • Cataract with significant vision loss \<5/10
• • Chorioretinal neovascularization
• • Subject in exclusion period determined by previous or current study
• • Impossibility to give the subject information enlightened (subject in emergency situation, difficulties of understanding the subject, ...)
• • Subject under the protection of justice
• • Subject under guardianship or curatorship
• • Pregnancy / Breastfeeding