Sleep for Stroke Management and Recovery Trial
Launched by UNIVERSITY OF MICHIGAN · Jan 18, 2019
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
The Sleep for Stroke Management and Recovery Trial is a study investigating whether treating a condition called obstructive sleep apnea (OSA) with a device that helps keep the airway open (called CPAP) can help patients who have recently had an ischemic stroke. The goal is to see if starting this treatment soon after the stroke can lower the chances of having another stroke or serious heart problems and improve recovery after three months.
To participate in this trial, patients must have had a stroke within the last week and be able to respond to some basic assessments. The study is open to all adults aged 65 to 74. Participants will receive the CPAP treatment and will be monitored to see how it affects their health over the next few months. It’s important to note that some people, such as those who cannot consent or have certain medical conditions, may not be eligible to join the study.
Gender
ALL
Eligibility criteria
- Current Inclusion Criteria, as of 6/28/2024:
- • 1. Ischemic stroke within the prior 7 days.
- • 2. NIH Stroke Scale Score ≥1 at the time of enrollment
- Previous Inclusion Criteria, prior to 6/28/2024:
- • 1. Ischemic stroke or TIA with ABCD ≥4, within prior 14 days.
- Exclusion Criteria (for entire time period):
- • 1. pre-event inability to perform all of own basic ADLs
- • 2. unable to obtain informed consent from subject or legally authorized representative
- • 3. incarcerated
- • 4. known pregnancy
- • 5. current mechanical ventilation (can enroll later if this resolves) or tracheostomy
- • 6. current use of positive airway pressure, or use within one month prior to stroke
- • 7. anatomical or dermatologic anomaly that makes use of CPAP interface unfeasible
- • 8. severe bullous lung disease
- • 9. history of prior spontaneous pneumothorax or current pneumothorax
- • 10. hypotension requiring current treatment with pressors (can enroll later if this resolves)
- • 11. other specific medical circumstances that conceivably, in the opinion of the site PI, could render the patient at risk of harm from use of CPAP
- • 12. massive epistaxis or previous history of massive epistaxis
- • 13. cranial surgery or head trauma within the past 6 months, with known or possible CSF leak or pneumocephalus
- • 14. recent hemicraniectomy or suboccipital craniectomy (i.e. those whose bone has not yet been replaced), or any other recent bone removal procedure for relief of intracranial pressure
- • 15. current receipt of oxygen supplementation \>4 liters per minute
- • 16. current contact, droplet, respiratory/airborne precautions
About University Of Michigan
The University of Michigan, a leading academic institution renowned for its commitment to advancing healthcare and medical research, serves as a prominent clinical trial sponsor. With a robust infrastructure that supports innovative research initiatives, the university leverages its multidisciplinary expertise to conduct a wide array of clinical trials aimed at improving patient outcomes and advancing medical knowledge. Through its state-of-the-art facilities and collaborative environment, the University of Michigan fosters partnerships between researchers, clinicians, and industry leaders, ensuring the development of cutting-edge therapies and interventions that address pressing health challenges.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Philadelphia, Pennsylvania, United States
Boston, Massachusetts, United States
Brooklyn, New York, United States
Boston, Massachusetts, United States
Chicago, Illinois, United States
Baltimore, Maryland, United States
Bronx, New York, United States
Iowa City, Iowa, United States
Saint Louis, Missouri, United States
Boston, Massachusetts, United States
Kalamazoo, Michigan, United States
Maywood, Illinois, United States
Bridgeport, Connecticut, United States
Detroit, Michigan, United States
Cincinnati, Ohio, United States
La Crosse, Wisconsin, United States
Los Angeles, California, United States
Manhasset, New York, United States
Boston, Massachusetts, United States
Sarasota, Florida, United States
Staten Island, New York, United States
Tulsa, Oklahoma, United States
Jacksonville, Florida, United States
Cleveland, Ohio, United States
Louisville, Kentucky, United States
Jackson, Mississippi, United States
Chicago, Illinois, United States
Miami, Florida, United States
Portland, Oregon, United States
Washington, District Of Columbia, United States
Clearwater, Florida, United States
Springfield, Illinois, United States
Boston, Massachusetts, United States
Omaha, Nebraska, United States
Seattle, Washington, United States
Cleveland, Ohio, United States
Hartford, Connecticut, United States
Downey, California, United States
Syracuse, New York, United States
Sacramento, California, United States
Dallas, Texas, United States
Miami, Florida, United States
Columbia, South Carolina, United States
Edison, New Jersey, United States
Detroit, Michigan, United States
Peoria, Illinois, United States
Tampa, Florida, United States
Springfield, Illinois, United States
Birmingham, Alabama, United States
Rochester, New York, United States
Cincinnati, Ohio, United States
Tampa, Florida, United States
Grand Rapids, Michigan, United States
Kansas City, Missouri, United States
Murray, Utah, United States
Minneapolis, Minnesota, United States
Springfield, Missouri, United States
Greenville, South Carolina, United States
Columbia, Missouri, United States
Richmond, Virginia, United States
Winston Salem, North Carolina, United States
Atlanta, Georgia, United States
Pittsburgh, Pennsylvania, United States
Los Angeles, California, United States
New Haven, Connecticut, United States
Buffalo, New York, United States
Houston, Texas, United States
Carmichael, California, United States
Danville, Pennsylvania, United States
Phoenix, Arizona, United States
Sylmar, California, United States
Knoxville, Tennessee, United States
New York, New York, United States
Falls Church, Virginia, United States
Flint, Michigan, United States
Miami, Florida, United States
Murray, Utah, United States
Orange, California, United States
Charlottesville, Virginia, United States
Grand Rapids, Michigan, United States
Chandler, Arizona, United States
San Diego, California, United States
Columbus, Ohio, United States
Harlingen, Texas, United States
Toledo, Ohio, United States
Chicago, Illinois, United States
Springfield, Massachusetts, United States
Portland, Oregon, United States
Albuquerque, New Mexico, United States
Seattle, Washington, United States
Salt Lake City, Utah, United States
Jacksonville, Florida, United States
New York, New York, United States
West Chester, Ohio, United States
Grand Junction, Colorado, United States
Santa Ana, California, United States
Jacksonville, Florida, United States
Shreveport, Louisiana, United States
Sioux Falls, South Dakota, United States
Phoenix, Arizona, United States
Morgantown, West Virginia, United States
Phoenix, Arizona, United States
Saint Louis, Missouri, United States
Pomona, California, United States
Tucson, Arizona, United States
Tucson, Arizona, United States
La Jolla, California, United States
Los Angeles, California, United States
Modesto, California, United States
Ontario, California, United States
San Francisco, California, United States
Walnut Creek, California, United States
Gainesville, Florida, United States
Edgewood, Kentucky, United States
Lexington, Kentucky, United States
Louisville, Kentucky, United States
New Orleans, Louisiana, United States
Rochester, Minnesota, United States
Saint Cloud, Minnesota, United States
Brooklyn, New York, United States
New York, New York, United States
Charlotte, North Carolina, United States
Concord, North Carolina, United States
Greensboro, North Carolina, United States
Fargo, North Dakota, United States
Cleveland, Ohio, United States
Bethlehem, Pennsylvania, United States
Hershey, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Memphis, Tennessee, United States
Dallas, Texas, United States
Burlington, Vermont, United States
Madison, Wisconsin, United States
Livingston, New Jersey, United States
Neptune, New Jersey, United States
Grand Rapids, Michigan, United States
La Jolla, California, United States
Worcester, Massachusetts, United States
Redwood City, California, United States
Fort Lauderdale, Florida, United States
Des Moines, Iowa, United States
Patients applied
Trial Officials
Devin Brown, MD, MS
Principal Investigator
University of Michigan
Ronald Chervin, MD, MS
Principal Investigator
University of Michigan
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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