Neuropsychological Assessment of Children and Adolescents With Turner Syndrome

Launched by UNIVERSITY HOSPITAL, ANGERS · Jan 17, 2019

Keywords

ClinConnect Summary

This clinical trial is studying how Turner syndrome (TS), a rare condition affecting girls, impacts their thinking and social skills. Specifically, the researchers want to understand the challenges these young girls face when it comes to making friends, understanding emotions, and managing their own feelings. The study will involve 70 girls aged between 7 and 16 years, including 35 with Turner syndrome and 35 with isolated growth hormone deficiency (a different condition affecting growth). Researchers will use a variety of tests and questionnaires to assess the girls' cognitive (thinking) and social abilities, which may help explain the social difficulties some of them experience.

To participate in this trial, girls need to be diagnosed with either Turner syndrome or isolated growth hormone deficiency and must be between 7 and 16 years old. Both the girls and their parents must give consent to join the study. Participants will not be eligible if they have certain other medical conditions, intellectual disabilities, or significant sensory issues that could interfere with the testing. This study could provide valuable insights into the experiences of girls with Turner syndrome and help improve their social and emotional well-being in the future.

Gender

FEMALE

Eligibility criteria

• • INCLUSION CRITERIA
• Turner syndrome group :
• • girls with diagnosed Turner syndrome.
• Isolated GHD group :
• • girls with diagnosed isolated growth hormone deficiency
• All participants :
• • age between 7 years to 16 years and 11 months.
• • informed consent signed by the participant and her parents (or her legal representatives)
• • being registered in the national social security system
• EXCLUSION CRITERIA :
• Turner syndrome group :
• • patients with chronic pathology other than Turner syndrome.
• • karyotype : part of a Y chromosome and r(X) cases.
• • medical treatment other than those usually prescribed in patients with Turner syndrome.
• Isolated GHD group :
• • patients with chronic pathology other than isolated growth hormone deficiency.
• • medical treatment other than those usually prescribed in patients with isolated growth hormone deficiency.
• All participants :
• • diagnosed intellectual disability (IQ\<70) or intellectual giftedness
• • history of acquired brain injury
• • sensory disturbances (auditory or visual) incompatible with the achievement of neuropsychological tasks.
• • insufficient French language proficiency