Pilot and Feasibility Study of 2'-FL as a Dietary Supplement in IBD Patients Receiving Stable Maintenance Anti-TNF Therapy

Launched by CHILDREN'S HOSPITAL MEDICAL CENTER, CINCINNATI · Feb 18, 2019

Keywords

ClinConnect Summary

This clinical trial is looking at a dietary supplement called 2'-FL to see if it can help patients with Inflammatory Bowel Disease (IBD), such as Crohn's Disease and Ulcerative Colitis, who are already receiving stable treatment with medications known as anti-TNF therapies. The researchers want to find out if taking different amounts of 2'-FL is safe and if it can increase certain healthy bacteria in the gut while also improving gut health markers. Participants in the study will be divided into groups to receive either 1, 5, or 10 grams of 2'-FL or a placebo (a sugar pill) daily for a period of time.

To be eligible for this trial, participants need to be between 11 and 25 years old and have been diagnosed with Crohn's Disease or Ulcerative Colitis that is currently stable (meaning their symptoms are under control). They should not be taking corticosteroids and must have been on a stable anti-TNF medication for at least 12 weeks. Participants will also need to agree not to make significant changes to their diet during the study. If you or someone you know is interested in joining this study, it's a great opportunity to contribute to research that could help improve treatment options for IBD.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Provision of signed and dated informed consent form
• • 2. Stated willingness to comply with all study procedures and availability for the duration of the study
• • 3. Male or female, aged 11 - 25
• • 4. Diagnosed with Crohns Disease or Ulcerative Colitis
• • 5. Disease is in remission
• • Adult CD (age 18-25): CDAI score \< 150
• • Pediatric CD (age 11-17): wPCDAI \< 12.5
• • Adult UC (age 18-25): Modified Mayo sub-scores: stool frequency sub-score=0, rectal bleeding sub-score=0
• • Pediatric UC (age 11-17): PUCAI score \< 10
• • 6. Not receiving corticosteroids
• • 7. Receiving a stable anti-TNF maintenance dose of adalimumab, infliximab, or the biosimilar infliximab-dyyb for 12 weeks prior to enrollment. A stable infliximab or infliximab-dyyb dose may range from 5 mg/kg every 8 weeks to 10 mg/kg every 4 weeks. A stable adalimumab dose may range from 20 mg every 2 weeks to 40 mg every 7 days. While therapeutic drug monitoring will not be required for inclusion, all drug and anti-drug antibody levels obtained for clinical indications within six months prior to enrollment, and from the screening visit through week 20, will be recorded.
• • 8. If receiving mesalamine, mercaptopurine, azathioprine, or methotrexate, must be on a stable dose for at least 12 weeks prior to enrollment.
• • 9. Agreement to not make any major dietary changes throughout study duration. This would include changing usual diet to a vegan diet, Specific Carbohydrate Diet (SCD), or exclusive enteral nutrition (EEN) diet.
• • 10. We will include CD patients who have had one ileo-colic resection, as long as the resection did not include more of the colon than the cecum and ascending colon. CD patients may be enrolled if at least six months post-surgery.
• Exclusion Criteria:
• • 1. Experienced active IBD clinical disease during the previous six months as determined by the Principal Investigator.
• • 2. Use of any of the following medications during the previous month: antibiotics, probiotics or prebiotics
• • 3. Diagnosis of celiac disease, diabetes or other co-morbidity that is determined by the PI as being exclusionary
• • 4. Treatment with another investigational drug or other intervention within 4 weeks
• • 5. Treatment with other biologic medication for IBD within prior 12 weeks
• • 6. Problem with lactose breakdown
• • 7. Currently pregnant or breast feeding
• • 8. We will exclude CD patients with more than one IBD related surgery, or those with a sub-total colectomy. We will exclude UC patients with colectomy or IBD related surgery.
• • 9. We will not allow concomitant use of anti-diarrheal medications.