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Search / Trial NCT03849534

Treatment of Temporomandibular Disorders in Children and Adolsecents

Launched by KAROLINSKA INSTITUTET · Feb 20, 2019

Trial Information

Current as of June 26, 2025

Recruiting

Keywords

Children Mixed Dentition Primary Dentition Adolescents Myalgia Arthralgia Of Tmj Treatment Side Effects

ClinConnect Summary

This clinical trial is studying how effective different treatments are for children and adolescents aged 7 to 14 who have temporomandibular disorders (TMD), which includes pain in the jaw and face. The researchers want to find out if treatments commonly used for adults, like special mouth guards (called occlusal appliances), jaw exercises, and anti-inflammatory medications (like NSAIDs), work well for younger patients. They are particularly interested in understanding whether these treatments help relieve pain and if they might cause any problems with jaw growth.

To participate in the study, children need to have a specific type of jaw pain that has been measured as moderate to severe on a pain scale. They will not be able to join if they have certain other health conditions, like severe joint or muscle diseases. If eligible, participants can expect to receive one or more of the treatments being tested and will be monitored closely for any changes in their pain and overall jaw function. This research aims to provide valuable information about how to better treat TMD in young patients.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • age 7-14 years
  • a diagnosis of myalgia or arthralgia according to DC/TMD
  • self-assessed average TMD pain intensity of ≥ 30 mm on a 100-mm visual analogue scale (VAS) during one week prior to examination.
  • The patients will remain included with one or several co-diagnoses of:
  • disc displacement with or without reduction according to DC/TMD
  • degenerative joint disease.
  • Exclusion Criteria:
  • diagnosed systemic muscular or joint diseases (e.g. fibromyalgia, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis)
  • whiplash associated disorder (WAD)
  • neuropathic pain or neurological disorders (e.g. myasthenia gravis, orofacial dystonia)
  • history of psychiatric disorders, and 5) pain of dental origin.

About Karolinska Institutet

Karolinska Institutet is a renowned medical university located in Sweden, recognized for its commitment to advancing healthcare through innovative research and education. As a leading sponsor of clinical trials, the institution focuses on translating scientific discoveries into effective treatments and therapies, emphasizing patient-centered approaches. With a strong emphasis on collaboration and interdisciplinary research, Karolinska Institutet plays a pivotal role in addressing global health challenges and improving patient outcomes, leveraging its extensive network of experts and state-of-the-art facilities to drive clinical advancements.

Locations

Huddinge, , Sweden

Patients applied

0 patients applied

Trial Officials

Nikolaos Christidis, PhD

Principal Investigator

Karolinska Institutet, Department of Dental Medicine

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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