Fibro-inflammatory Progression From Acute to Chronic Pancreatitis

Launched by COPENHAGEN UNIVERSITY HOSPITAL, HVIDOVRE · Feb 22, 2019

Keywords

ClinConnect Summary

This clinical trial is studying how inflammation and scarring in the pancreas develop from acute pancreatitis (a sudden inflammation of the pancreas) to chronic pancreatitis (long-lasting inflammation). Researchers want to understand this process better by looking at imaging tests (like scans) and measuring certain markers in the blood that indicate inflammation and scarring. The goal is to learn how to predict who might go from having a first-time attack of acute pancreatitis to developing chronic pancreatitis.

The trial is currently recruiting participants aged between 65 and 75 years old, and it is open to everyone regardless of gender. To be eligible, individuals must have one of the following: chronic pancreatitis that isn't caused by gallstones, their first episode of acute pancreatitis, or recurrent acute pancreatitis (which means they have had two or more episodes). Participants can expect to undergo some tests and provide blood samples, helping researchers gather important information about this condition. This study aims to improve understanding and treatment of pancreatitis, ultimately benefiting many patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with CP (N=50) of any aetiology except gallstone induced CP: CP will be diagnosed based on MANNHEIM criteria .
• • Cohort 2: Patients with their first attack of AP of any aetiology except gallstone induced AP (N=50). The revised Atlanta criteria for acute pancreatitis will be used as diagnostic criteria.
• • Cohort 3: Patients with RAP (N=50) except gallstone induced RAP. RAP is defined as two or more cases of AP as diagnosed by the revised Atlanta Criteria.
• Exclusion Criteria: