Respiratory Muscle Strength in Patients With Obesity Hypoventilation Syndrome (OHS) or With a Precursor of the Disease

Launched by WISSENSCHAFTLICHES INSTITUT BETHANIEN E.V · Feb 21, 2019

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how strong the muscles that help us breathe are in people who have a condition called Obesity Hypoventilation Syndrome (OHS) or are at risk for developing it. The researchers want to find out what factors might lead to OHS and how to identify patients who may experience breathing problems while sleeping due to this condition.

To participate in the trial, individuals need to be between 18 and 80 years old, have a body mass index (BMI) over 30, and either have different stages of OHS or a higher risk for it. Unfortunately, people with certain other medical conditions like severe heart issues or those who cannot give their consent will not be eligible. If you join the study, you will undergo various tests to measure your breathing muscle strength. This research is important because it may help in finding better ways to treat and manage OHS in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • patients with BMI \> 30 and obesity-associated hypoventilation stages I - IV
• • patients with BMI \> 30 and elevated OHS-risk (= obstructive sleep apnea without hypercapnia)
• • age:18-80 years
• • capacity to consent
• Exclusion Criteria:
• • any other disease, that causes ventilatory insufficiency
• • pacemaker, defibrillators or device for deep brain or vagus nerve stimulation
• • esophagitis, Barrett-esophagus, esophageal cancer
• • acute gastritis and ulcera ventriculi
• • epilepsy
• • any medical, psychological or other condition impairing the patient's ability to provide informed consent