Exercise and Nutrition Interventions During Chemotherapy K07

Launched by UNIVERSITY OF ROCHESTER · Feb 26, 2019

Keywords

ClinConnect Summary

This clinical trial, titled "Exercise and Nutrition Interventions During Chemotherapy," is studying ways to help women with breast cancer who suffer from a painful condition called chemotherapy-induced peripheral neuropathy (CIPN). This condition often affects patients who receive taxane chemotherapy, causing symptoms like tingling, numbness, or pain in the hands and feet. The trial aims to find out whether exercise or nutrition education can effectively reduce these symptoms and to learn more about how inflammation and body awareness might play a role in CIPN.

To be eligible for this trial, participants must be women aged 18 or older who are scheduled to receive taxane chemotherapy for breast cancer and have a life expectancy of at least six months. They should not be active in an exercise program or have any serious physical limitations that would prevent them from participating. If you join the study, you can expect to engage in either an exercise program or receive nutrition education, which may help improve your symptoms. This trial is currently recruiting participants, and your involvement could contribute to important research that may lead to better treatment options for CIPN in the future.

Gender

FEMALE

Eligibility criteria

• • Inclusion criteria (subjects must...)
• • 1. Be female
• • 2. Have breast cancer
• • 3. Be scheduled to receive taxane chemotherapy without other neurotoxic chemotherapy (platinums, vinca alkaloids, bortezomib, thalidomide)
• • 4. Have at least six months life expectancy according to the patient's oncologist or designee
• • 5. Be able to read English
• • 6. Be at least 18 years old (no upper limit on age)
• • 7. Provide written informed consent
• • Exclusion criteria (subjects must not...)
• • 1. Be in the active or maintenance stage of exercise behavior (i.e., subjects must be sedentary)
• • 2. Have physical limitations (e.g., cardiorespiratory, orthopedic, central nervous system) that contraindicate participation in maximal physiological fitness testing and a low/moderate intensity home-based walking and progressive resistance exercise program.
• • Additional exclusion criteria only for patients performing the MRI scanning (40 of 80 enrolled subjects)
• • 1. Subjects must not have contraindications for MRI scanning (pacemaker, metal implants, pregnancy, chest expander from breast reconstruction, etc.-note that most port-a-caths are safe for MRI scanning)