Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke
Launched by AMGEN · Mar 11, 2019
Trial Information
Current as of May 10, 2025
Active, not recruiting
Keywords
ClinConnect Summary
This clinical trial is studying the effects of a medication called evolocumab on heart health in adults who are at high risk for heart problems but have not yet had a heart attack or stroke. The goal is to see how well this medication can lower levels of “bad” cholesterol (known as LDL-C) and whether it helps prevent major heart-related events, like heart attacks or strokes, in people with specific heart conditions or risk factors.
To participate in the trial, adults aged 50 to 80 years old may be eligible if they have high cholesterol levels and evidence of heart disease or diabetes. Participants will be monitored throughout the study to see how the treatment affects their cholesterol levels and overall heart health. It’s important to note that individuals who have had a heart attack or stroke in the past, or have certain severe heart conditions, cannot join the trial. This study is currently active but not recruiting new participants.
Gender
ALL
Eligibility criteria
- Inclusion criteria:
- • 1. Age: Adult subjects ≥ 50 (men) or ≥ 55 (women) to ˂ 80 years of age (either sex) and meeting lipid criteria
- • 2. Low-density lipoprotein cholesterol (LDL-C) ≥ 90 mg/dL (≥ 2.3 mmol/L) or non-high-density lipoprotein cholesterol (non-HDL) ≥ 120 mg/dL (≥ 3.1 mmol/L), or apolipoprotein B ≥ 80 mg/dL (≥ 1.56 µmol/L)
- 3. Evidence of at least one of the following at screening (without prior myocardial infarction or stroke):
- • A. Significant coronary artery disease (CAD) B. Significant atherosclerotic cerebrovascular disease C. Significant peripheral arterial disease D. Diabetes mellitus
- • 4. At least 1 high-risk feature
- • Exclusion criteria
- • MI or stroke prior to randomization
- • Coronary artery bypass grafting (CABG) ˂ 3 months prior to screening
- • Estimated glomerular filtration rate (eGFR) ˂ 15 mL/min/1.73 m²
- • Uncontrolled or recurrent ventricular tachycardia in the absence of an implantable-cardioverter defibrillator.
- • Atrial fibrillation or atrial flutter not on anticoagulation therapy (vitamin K antagonist, heparin, low molecular weight heparin, fondaparinux,or non-Vitamin K antagonist oral anticoagulant)
- • Triglycerides ≥ 500 mg/dL (5.7 mmol/L) measured up to 3 months prior to screening. The most recent results must be used.
- • Last measured left-ventricular ejection fraction ˂ 30% or New York Heart Association (NYHA) Functional Class III/IV
- • Planned arterial revascularization
About Amgen
Amgen is a leading global biotechnology company dedicated to discovering, developing, manufacturing, and delivering innovative human therapeutics. With a strong focus on areas such as oncology, cardiovascular disease, and inflammation, Amgen leverages advanced science and technology to address complex medical needs. The company is committed to improving patient outcomes through rigorous clinical trials and robust research initiatives, ensuring the highest standards of safety and efficacy in its products. With a rich pipeline of cutting-edge therapies, Amgen continues to be at the forefront of biopharmaceutical advancements, making a significant impact on healthcare worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Amsterdam, , Netherlands
Adelaide, South Australia, Australia
Nijmegen, , Netherlands
Bournemouth, , United Kingdom
Liverpool, New South Wales, Australia
Traverse City, Michigan, United States
Madrid, , Spain
Madrid, , Spain
Manchester, , United Kingdom
Scunthorpe, , United Kingdom
Pittsburgh, Pennsylvania, United States
Paris, , France
Providence, Rhode Island, United States
Thessaloniki, , Greece
Garran, Australian Capital Territory, Australia
Hobart, Tasmania, Australia
Dirksland, , Netherlands
Gouda, , Netherlands
Zaandam, , Netherlands
Antwerpen, , Belgium
Paris, , France
Winston Salem, North Carolina, United States
Winston Salem, North Carolina, United States
Portland, Oregon, United States
Ocala, Florida, United States
Little Rock, Arkansas, United States
Cincinnati, Ohio, United States
Chapel Hill, North Carolina, United States
Belfast, , United Kingdom
Jacksonville, Florida, United States
Paris, , France
Glasgow, , United Kingdom
Nottingham, , United Kingdom
Saint Cloud, Minnesota, United States
Miami, Florida, United States
Hillerod, , Denmark
Sarasota, Florida, United States
Madrid, , Spain
Boston, Massachusetts, United States
Minneapolis, Minnesota, United States
London, , United Kingdom
Camperdown, New South Wales, Australia
New Hyde Park, New York, United States
Aberdeen, , United Kingdom
Port Charlotte, Florida, United States
Asheville, North Carolina, United States
Madrid, , Spain
Yeovil, , United Kingdom
Kansas City, Missouri, United States
Hobart, , Australia
Arnhem, , Netherlands
Bath, , United Kingdom
Daytona Beach, Florida, United States
Dundee, , United Kingdom
Clayton, Victoria, Australia
Winnipeg, Manitoba, Canada
Eindhoven, , Netherlands
Breda, , Netherlands
Aalborg, , Denmark
Pamplona, Navarra, Spain
Milano, , Italy
Helsinki, , Finland
Utrecht, , Netherlands
Taichung, , Taiwan
Taipei, , Taiwan
Leeuwarden, , Netherlands
Ulm, , Germany
Heidelberg, , Germany
Madrid, , Spain
Liverpool, , United Kingdom
Venlo, , Netherlands
Rotterdam, , Netherlands
Kaohsiung, , Taiwan
Seoul, , Korea, Republic Of
Athens, , Greece
Mannheim, , Germany
Tainan, , Taiwan
Seoul, , Korea, Republic Of
Rouen, , France
Lodz, , Poland
Littleton, Colorado, United States
Golden, Colorado, United States
Brandon, Florida, United States
Praha 2, , Czechia
Almada, , Portugal
Biddeford, Maine, United States
Salisbury, North Carolina, United States
Summerville, South Carolina, United States
Odessa, Texas, United States
Mount Pearl, Newfoundland And Labrador, Canada
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Elyria, Ohio, United States
Marseille Cedex 08, , France
Paris, , France
Leipzig, , Germany
Viborg, , Denmark
Pensacola, Florida, United States
Alexandria, Louisiana, United States
Slidell, Louisiana, United States
Dallas, Texas, United States
Busan, , Korea, Republic Of
Falun, , Sweden
Jonkoping, , Sweden
Umea, , Sweden
Gwangju, , Korea, Republic Of
Aalst, , Belgium
Gwangju, , Korea, Republic Of
Svendborg, , Denmark
Zwijndrecht, , Netherlands
Tampere, , Finland
Evansville, Indiana, United States
Nuneaton, , United Kingdom
Worcester, , United Kingdom
Seoul, , Korea, Republic Of
Deventer, , Netherlands
Potsdam, , Germany
Montreal, Quebec, Canada
Bucharest, , Romania
Gdansk, , Poland
Witten, , Germany
Roseville, California, United States
Seoul, , Korea, Republic Of
Daugavpils, , Latvia
Athens, , Greece
Heraklion, , Greece
Ioannina, , Greece
Thessaloniki, , Greece
Budapest, , Hungary
Feldkirch, , Austria
Praha 5, , Czechia
Oulu, , Finland
Cleveland, Ohio, United States
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Graz, , Austria
Utrecht, , Netherlands
Tallinn, , Estonia
Regensburg, , Germany
Kassel, , Germany
Magdeburg, , Germany
Little Rock, Arkansas, United States
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Barnsley, , United Kingdom
Liverpool, , Australia
Brno, , Czechia
Taipei, , Taiwan
El Palmar, Murcia, Spain
Murdoch, Western Australia, Australia
London, , United Kingdom
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Esbjerg, , Denmark
Santa Fe, , Argentina
Porto Alegre, Rio Grande Do Sul, Brazil
Zwolle, , Netherlands
A Coruña, Galicia, Spain
Silkeborg, , Denmark
Budapest, , Hungary
Münster, , Germany
Larissa, , Greece
Leiden, , Netherlands
Samara, , Russian Federation
Stevenage, , United Kingdom
Seoul, , Korea, Republic Of
Athens, , Greece
Torino, , Italy
Charlotte, North Carolina, United States
Sarasota, Florida, United States
Heerlen, , Netherlands
Ede, , Netherlands
Leamington Spa, , United Kingdom
Halifax, Nova Scotia, Canada
Tomball, Texas, United States
Helmond, , Netherlands
Busan, , Korea, Republic Of
Budapest, , Hungary
Aarhus N, , Denmark
Kielce, , Poland
Newmarket, Ontario, Canada
Maroubra, New South Wales, Australia
Taichung, , Taiwan
Torquay, , United Kingdom
Nijmegen, , Netherlands
Corbeil Essonnes, , France
Targu Mures, , Romania
Palm Springs, California, United States
Riga, , Latvia
Milano, , Italy
Delft, , Netherlands
Beverwijk, , Netherlands
Praha 4, , Czechia
Toulouse Cedex 3, , France
Roma, , Italy
Lublin, , Poland
Stamford, Connecticut, United States
Daytona Beach, Florida, United States
Pecs, , Hungary
Seoul, , Korea, Republic Of
Coeur D'alene, Idaho, United States
Saratoga Springs, New York, United States
Kaohsiung, , Taiwan
Kaohsiung, , Taiwan
Debrecen, , Hungary
Tulsa, Oklahoma, United States
Doylestown, Pennsylvania, United States
Michigan City, Indiana, United States
Bucuresti, , Romania
Santiago De Compostela, Galicia, Spain
Amersfoort, , Netherlands
Sofia, , Bulgaria
Miami, Florida, United States
Chicoutimi, Quebec, Canada
Gdansk, , Poland
Seoul, , Korea, Republic Of
Kolding, , Denmark
Pisa, , Italy
Frankfurt Am Main, , Germany
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Dallas, Texas, United States
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Tiel, , Netherlands
Crawley, , United Kingdom
Whitby, , United Kingdom
Hasselt, , Belgium
Murdoch, , Australia
Innsbruck, , Austria
Daegu, , Korea, Republic Of
Beverly Hills, California, United States
Lincoln, Nebraska, United States
Budapest, , Hungary
San Donato Milanese, , Italy
Hamburg, , Germany
Roma, , Italy
Katowice, , Poland
Baltimore, Maryland, United States
Groningen, , Netherlands
Chesterfield, , United Kingdom
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Athens, , Greece
Goes, , Netherlands
Szolnok, , Hungary
Milton, Queensland, Australia
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Jyvaskyla, , Finland
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Alkmaar, , Netherlands
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Wien, , Austria
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Kuopio, , Finland
München, , Germany
Iasi, , Romania
West Bromwich, , United Kingdom
Warszawa, , Poland
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Hull, , United Kingdom
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Hoogeveen, , Netherlands
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Eger, , Hungary
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Miskolc, , Hungary
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Tilburg, , Netherlands
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Corrientes, , Argentina
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Mainz, , Germany
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Gyongyos, , Hungary
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Springfield, Ohio, United States
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Berlin, , Germany
Carnaxide, , Portugal
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Mar Del Plata, , Argentina
Tallinn, , Estonia
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Szentes, , Hungary
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Praha 10, , Czechia
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Rotterdam, , Netherlands
Norman, Oklahoma, United States
Campina Grande Do Sul, Paraná, Brazil
Bangor, Maine, United States
Antwerpen, , Belgium
Gozee, , Belgium
Aalborg, , Denmark
Ballerup, , Denmark
Kobenhavn S, , Denmark
Vejle, , Denmark
Le Coudray, , France
Montpellier Cedex 05, , France
Nantes Cedex 1, , France
Pau, , France
Toulouse Cedex 9, , France
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Dortmund, , Germany
Milano, , Italy
Ostersund, , Sweden
Stockholm, , Sweden
Fargo, North Dakota, United States
Udine, , Italy
Nieuwegein, , Netherlands
Schiedam, , Netherlands
Herlev, , Denmark
Leuven, , Belgium
Szeged, , Hungary
Seoul, , Korea, Republic Of
Lufkin, Texas, United States
Saint Petersburg, , Russian Federation
Gyula, , Hungary
Wroclaw, , Poland
Camp Hill, Pennsylvania, United States
Apeldoorn, , Netherlands
Jozefow, , Poland
Ciudad Autonoma De Buenos Aires, Buenos Aires, Argentina
Reus, Cataluña, Spain
Daegu, , Korea, Republic Of
Rennes, , France
Bristol, , United Kingdom
Corby, , United Kingdom
Poole, , United Kingdom
Zaragoza, Aragón, Spain
Coventry, , United Kingdom
Sevilla, Andalucía, Spain
Kaohsiung, , Taiwan
Dresden, , Germany
Villingen Schwenningen, , Germany
Poznan, , Poland
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Madrid, , Spain
Bossier City, Louisiana, United States
Mckinney, Texas, United States
Fort Mill, South Carolina, United States
Karlstad, , Sweden
Kyiv, , Ukraine
Wonju Si, Gangwon Do, , Korea, Republic Of
Balatonfured, , Hungary
Rapid City, South Dakota, United States
Porto Alegre, Rio Grande Do Sul, Brazil
Seongnam Si, Gyeonggi Do, , Korea, Republic Of
Badalona, Cataluña, Spain
Wien, , Austria
Bologna, , Italy
Nijmegen, , Netherlands
Taoyuan, , Taiwan
Budapest, , Hungary
Bundaberg, Queensland, Australia
Kaunas, , Lithuania
Vilnius, , Lithuania
Tilburg, , Netherlands
Birmingham, Alabama, United States
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Eunice, Louisiana, United States
Hammond, Louisiana, United States
Natchitoches, Louisiana, United States
Shreveport, Louisiana, United States
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Salisbury, Maryland, United States
Framingham, Massachusetts, United States
Flint, Michigan, United States
Grand Rapids, Michigan, United States
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Duluth, Minnesota, United States
Great Falls, Montana, United States
Omaha, Nebraska, United States
Las Vegas, Nevada, United States
Voorhees, New Jersey, United States
Cheektowaga, New York, United States
Kingston, New York, United States
Manhasset, New York, United States
New York, New York, United States
Poughkeepsie, New York, United States
Southampton, New York, United States
Greensboro, North Carolina, United States
Mooresville, North Carolina, United States
Rocky Mount, North Carolina, United States
Marion, Ohio, United States
Sandusky, Ohio, United States
Camp Hill, Pennsylvania, United States
Jersey Shore, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Charleston, South Carolina, United States
Greenville, South Carolina, United States
Little River, South Carolina, United States
Murrells Inlet, South Carolina, United States
Kingwood, Texas, United States
Mesquite, Texas, United States
San Antonio, Texas, United States
San Antonio, Texas, United States
Suffolk, Virginia, United States
Puyallup, Washington, United States
Tacoma, Washington, United States
Caba, Buenos Aires, Argentina
Caba, Buenos Aires, Argentina
Caba, Buenos Aires, Argentina
Caba, Buenos Aires, Argentina
Caba, Buenos Aires, Argentina
Caba, Buenos Aires, Argentina
Caba, Buenos Aires, Argentina
Caba, Buenos Aires, Argentina
Caba, Buenos Aires, Argentina
Caba, Buenos Aires, Argentina
Ciudad Autonoma De Buenos Aires, Buenos Aires, Argentina
Ciudad Autonoma De Buenos Aires, Buenos Aires, Argentina
Ciudad Autonoma De Buenos Aires, Buenos Aires, Argentina
Moron, Buenos Aires, Argentina
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Cordoba, Córdoba, Argentina
Villa Maria, Córdoba, Argentina
Santa Rosa, La Pampa, Argentina
Rosario, Santa Fe, Argentina
Rosario, Santa Fe, Argentina
San Miguel De Tucuman, Tucuman, Argentina
San Miguel De Tucuman, Tucuman, Argentina
Córdoba, , Argentina
Salta, , Argentina
San Juan, , Argentina
San Luis, , Argentina
Auchenflower, Queensland, Australia
Fortitude Valley, Queensland, Australia
Adelaide, South Australia, Australia
Leabrook, South Australia, Australia
Berwick, Victoria, Australia
Epping, Victoria, Australia
Geelong, Victoria, Australia
Ringwood, Victoria, Australia
Bentley, Western Australia, Australia
Joondalup, Western Australia, Australia
Woolloongabba, , Australia
Klagenfurt, , Austria
Linz, , Austria
Wien, , Austria
Wien, , Austria
Aalst, , Belgium
Ham, , Belgium
Linkebeek, , Belgium
Mons, , Belgium
Pelt, , Belgium
Tessenderlo, , Belgium
Fortaleza, Ceará, Brazil
Brasília, Distrito Federal, Brazil
Belo Horizonte, Minas Gerais, Brazil
Belo Horizonte, Minas Gerais, Brazil
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Curitiba, Paraná, Brazil
Curitiba, Paraná, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Blumenau, Santa Catarina, Brazil
Campinas, São Paulo, Brazil
Campinas, São Paulo, Brazil
Marilia, São Paulo, Brazil
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São José Do Rio Preto, São Paulo, Brazil
Rio De Janeiro, , Brazil
São Paulo, , Brazil
Burgas, , Bulgaria
Haskovo, , Bulgaria
Pernik, , Bulgaria
Pleven, , Bulgaria
Pleven, , Bulgaria
Plovdiv, , Bulgaria
Plovdiv, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Stara Zagora, , Bulgaria
Veliko Tarnovo, , Bulgaria
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Weston, Ontario, Canada
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Montreal, Quebec, Canada
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Quebec, , Canada
Benatky Nad Jizerou, , Czechia
Beroun, , Czechia
Beroun, , Czechia
Brandys Nad Labem, , Czechia
Brno, , Czechia
Brno, , Czechia
Brno, , Czechia
Brno, , Czechia
Brno, , Czechia
Broumov, , Czechia
Ceske Budejovice, , Czechia
Havirov Mesto, , Czechia
Hodonin, , Czechia
Holesov, , Czechia
Hradec Kralove, , Czechia
Karlovy Vary, , Czechia
Kladno, , Czechia
Klatovy Iv, , Czechia
Kolin Iii, , Czechia
Liberec, , Czechia
Louny, , Czechia
Ludgerovice, , Czechia
Milevsko, , Czechia
Mlada Boleslav, , Czechia
Mohelnice, , Czechia
Ostrava Poruba, , Czechia
Ostrava Dubina, , Czechia
Ostrava, , Czechia
Pardubice, , Czechia
Pardubice, , Czechia
Plzen 1, , Czechia
Praha 10 Zabehlice, , Czechia
Praha 1, , Czechia
Praha 3, , Czechia
Praha 4, , Czechia
Praha 5 Smichov, , Czechia
Praha 5, , Czechia
Praha 9, , Czechia
Prerov, , Czechia
Rychnov Nad Kneznou, , Czechia
Svitavy, , Czechia
Teplice, , Czechia
Trinec, , Czechia
Uherske Hradiste, , Czechia
Uherske Hradiste, , Czechia
Zlin, , Czechia
Znojmo, , Czechia
Herlev, , Denmark
Herning, , Denmark
Kobenhavn O, , Denmark
Parnu, , Estonia
Tallinn, , Estonia
Helsinki, , Finland
Joensuu, , Finland
Jyvaskyla, , Finland
Kuopio, , Finland
Amiens Cedex 1, , France
Bron, , France
Caen Cedex 9, , France
Dijon, , France
Grenoble, , France
Grenoble, , France
Le Chesnay, , France
Lille, , France
Lyon Cédex 3, , France
Marseille Cedex 05, , France
Nice Cedex 1, , France
Nimes, , France
Bad Neuheim, , Germany
Bremen, , Germany
Dresden, , Germany
Dresden, , Germany
Frankfurt Am Main, , Germany
Fulda, , Germany
Markleeberg, , Germany
München, , Germany
Papenburg, , Germany
Rostock, , Germany
Singen, , Germany
Athens, , Greece
Athens, , Greece
Athens, , Greece
Athens, , Greece
Thessaloniki, , Greece
Thessaloniki, , Greece
Baja, , Hungary
Balatonkeresztur, , Hungary
Balloszog, , Hungary
Bekescsaba, , Hungary
Berettyoujfalu, , Hungary
Budapest, , Hungary
Budapest, , Hungary
Gyongyos, , Hungary
Hatvan, , Hungary
Kalocsa, , Hungary
Sopron, , Hungary
Szeged, , Hungary
Szekesfehervar, , Hungary
Zalaegerszeg, , Hungary
Kopavogur, , Iceland
Reykjavik, , Iceland
Augusta, , Italy
Catanzaro, , Italy
Chieti, , Italy
Massa, , Italy
Pozzuoli, , Italy
Cheongju Si, Chungcheongbuk Do, , Korea, Republic Of
Seoul, , Korea, Republic Of
Suwon Si, Gyeonggi Do, , Korea, Republic Of
Ogre, , Latvia
Ogre, , Latvia
Riga, , Latvia
Alytus, , Lithuania
Kaunas, , Lithuania
Kaunas, , Lithuania
Klaipeda, , Lithuania
Cd De Mexico, Distrito Federal, Mexico
Monterrey, Nuevo León, Mexico
Queretaro, Querétaro, Mexico
Culiacan, Sinaloa, Mexico
Aguascalientes, , Mexico
Chihuahua, , Mexico
Almelo, , Netherlands
Almere, , Netherlands
Amsterdam, , Netherlands
Den Haag, , Netherlands
Dordrecht, , Netherlands
Dordrecht, , Netherlands
Emmen, , Netherlands
Hoorn, , Netherlands
Rotterdam, , Netherlands
The Hague, , Netherlands
Uden, , Netherlands
Zwijndrecht, , Netherlands
Bydgoszcz, , Poland
Chrzanow, , Poland
Gdansk, , Poland
Gdynia, , Poland
Gdynia, , Poland
Gizycko, , Poland
Grodzisk Mazowiecki, , Poland
Kielce, , Poland
Krakow, , Poland
Krakow, , Poland
Krakow, , Poland
Krakow, , Poland
Krosno, , Poland
Leczna, , Poland
Lodz, , Poland
Lubin, , Poland
Lublin, , Poland
Lublin, , Poland
Lublin, , Poland
Miechow, , Poland
Nowy Targ, , Poland
Piaseczno, , Poland
Plock, , Poland
Pulawy, , Poland
Ruda Slaska, , Poland
Siedlce, , Poland
Skierniewice, , Poland
Staszow, , Poland
Szczecin, , Poland
Tarnow, , Poland
Torun, , Poland
Torun, , Poland
Torun, , Poland
Warszawa, , Poland
Warszawa, , Poland
Warszawa, , Poland
Wegrow, , Poland
Wloclawek, , Poland
Wroclaw, , Poland
Wroclaw, , Poland
Zamosc, , Poland
Aveiro, , Portugal
Faro, , Portugal
Guimaraes, , Portugal
Lisboa, , Portugal
Matosinhos, , Portugal
Viseu, , Portugal
Brasov, , Romania
Bucuresti, , Romania
Craiova, , Romania
Iasi, , Romania
Oradea, , Romania
Pitesti, , Romania
Targu Mures, , Romania
Arkhangelsk, , Russian Federation
Barnaul, , Russian Federation
Barnaul, , Russian Federation
Ekaterinburg, , Russian Federation
Ekaterinburg, , Russian Federation
Ivanovo, , Russian Federation
Izhevsk, , Russian Federation
Kemerovo, , Russian Federation
Kirov, , Russian Federation
Krasnodar, , Russian Federation
Krasnodar, , Russian Federation
Moscow, , Russian Federation
Moscow, , Russian Federation
Moscow, , Russian Federation
Moscow, , Russian Federation
Moscow, , Russian Federation
Nizhny Novgorod, , Russian Federation
Novosibirsk, , Russian Federation
Novosibirsk, , Russian Federation
Novosibirsk, , Russian Federation
Omsk, , Russian Federation
Perm, , Russian Federation
Ryazan, , Russian Federation
Saint Petersburg, , Russian Federation
Saint Petersburg, , Russian Federation
Saint Petersburg, , Russian Federation
Saint Petersburg, , Russian Federation
Saint Petersburg, , Russian Federation
Saint Petersburg, , Russian Federation
Sait Petersburg, , Russian Federation
Saratov, , Russian Federation
Smolensk, , Russian Federation
Sochi, , Russian Federation
St. Petersburg, , Russian Federation
Tomsk, , Russian Federation
Tyumen, , Russian Federation
Tyumen, , Russian Federation
Vladimir, , Russian Federation
Volgograd, , Russian Federation
Bardejov, , Slovakia
Bratislava, , Slovakia
Bratislava, , Slovakia
Bratislava, , Slovakia
Brezno, , Slovakia
Kosice, , Slovakia
Kosice, , Slovakia
Lucenec, , Slovakia
Moldava Nad Bodvou, , Slovakia
Namestovo, , Slovakia
Nitra, , Slovakia
Nove Zamky, , Slovakia
Presov, , Slovakia
Presov, , Slovakia
Roznava, , Slovakia
Snina, , Slovakia
Svidnik, , Slovakia
Trebisov, , Slovakia
Trencin, , Slovakia
Almeria, Andalucía, Spain
Cordoba, Andalucía, Spain
Granada, Andalucía, Spain
Malaga, Andalucía, Spain
Las Palmas De Gran Canarias, Canarias, Spain
Valladolid, Castilla León, Spain
Barcelona, Cataluña, Spain
Valencia, Comunidad Valenciana, Spain
Vigo, Galicia, Spain
Boras, , Sweden
Goteborg, , Sweden
Goteborg, , Sweden
Harnosand, , Sweden
Helsingborg, , Sweden
Lidkoping, , Sweden
Lund, , Sweden
Malmo, , Sweden
Varberg, , Sweden
Hualien, , Taiwan
New Taipei, , Taiwan
Ivano Frankivsk, , Ukraine
Kharkiv, , Ukraine
Kharkiv, , Ukraine
Kharkiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Uzhgorod, , Ukraine
Vinnytsia, , Ukraine
Vinnytsya, , Ukraine
Zaporizhzhia, , Ukraine
Belfast, , United Kingdom
Bollington, , United Kingdom
Burton Upon Trent, , United Kingdom
Cleveleys, , United Kingdom
Corby, , United Kingdom
Inverness, , United Kingdom
Northwood, , United Kingdom
Orpington, , United Kingdom
Penzance, , United Kingdom
Peterborough, , United Kingdom
Romford, , United Kingdom
Sandbach, , United Kingdom
Shipley, , United Kingdom
St Neots, , United Kingdom
Stamford, , United Kingdom
Thetford, , United Kingdom
Watford, , United Kingdom
Wokingham, , United Kingdom
Caba, , Argentina
Patients applied
Trial Officials
MD
Study Director
Amgen
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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