Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention

Launched by CHINESE UNIVERSITY OF HONG KONG · Mar 13, 2019

Keywords

ClinConnect Summary

This clinical trial is investigating how different treatments, like lifestyle changes or bariatric surgery, affect fat in the body, especially in the liver and pancreas, as well as cholesterol levels. The researchers hope to understand whether brown fat (a type of fat that helps burn calories) can be used as a marker to predict the development of Non-Alcoholic Fatty Liver Disease (NAFLD) in people who are overweight or obese. They will also look at how brown fat relates to obesity and NAFLD.

To participate in this study, you should be between 65 and 74 years old and have a body mass index (BMI) of 25 or higher. If you have a BMI of 30 or more and also have metabolic syndrome (a cluster of conditions that increase heart disease risk), or a BMI of 35 or more for morbid obesity, you may be eligible. However, if you have other liver diseases, take certain medications that affect liver fat, or have some specific health conditions, you may not qualify. Participants can expect to undergo assessments that measure changes in body fat and liver health throughout the study. This research could provide valuable insights into managing and preventing conditions like NAFLD and obesity.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • BMI ≥ 25-30 kg/m2
• • BMI ≥ 30 kg/m2 with Metabolic syndrome
• • BMI ≥ 35 kg/m2 for morbid obesity
• Exclusion Criteria:
• • Other kind of hepatic diseases
• • Under medications known to affect liver fat
• • Waist circumference ≥ 150 cm
• • Weight ≥ 250 kg
• • MRI contraindications