Cerebral Haemodynamics in Transient Ischaemic Attack

Launched by UNIVERSITY OF LEICESTER · Mar 20, 2019

Keywords

ClinConnect Summary

Adequate brain blood flow is essential for brain survival and function. Brain blood flow is kept relatively constant by a process called cerebral autoregulation (CA). CA is impaired in various diseases including head injury, diabetes, Alzheimer's dementia, pre-eclampsia and stroke. In stroke, impaired CA is associated with early deterioration and the need for emergency surgery to relieve brain swelling. Impaired CA in stroke has also been shown to be related to stroke severity and functional outcomes.

A transient ischaemic attack (TIA), also known as a mini-stroke, is the same as a stroke,...

Gender

ALL

Eligibility criteria

• INCLUSION CRITERIA:
• HEALTHY CONTROLS:
• • Willing to participate
• • Capacity to consent to the study
• • Aged over 18 years
• • Able (in the Investigator's opinion) and willing to comply with all study requirements
• • Good understanding of written and verbal English
• TIA PATIENTS:
• • Willing to participate
• • Capacity to consent to the study
• • Aged over 18 years
• • Able (in the Investigator's opinion) and willing to comply with all study requirements
• • A diagnosis of acute (≤7 days) TIA, made by a specialist in the TIA clinic at University Hospitals of Leicester NHS Trust that fulfils the 2009 American Heart Association definition of TIA
• • Good understanding of written and verbal English
• EXCLUSION CRITERIA:
• • ALL PARTICIPANTS (HEALTHY CONTROLS AND TIA PATIENTS)
• • Unwilling to take part
• • Unable to consent
• • Aged under 18 years
• • Unable (in the Investigator's opinion) or unwilling to comply with any study requirements
• • Female participants who are pregnant, lactating or planning pregnancy during the course of the study
• • A diagnosis of atrial fibrillation
• • A diagnosis of severe heart failure (Ejection Fraction \<30%)
• • Severe respiratory disease
• • Inadequate bilateral transcranial Doppler windows (see section 8.3)
• • Carotid stenosis ≥70% (unilateral or bilateral)
• • Participant enrolled in an interventional research study.
• • Poor understanding of written and verbal English