Biological Parameters Changes After Autologous Blood Transfusion of Red Blood Cells (200 Ml) in Healthy Volunteers.

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Mar 22, 2019

Keywords

ClinConnect Summary

This clinical trial is studying how autologous blood transfusions—where a person’s own blood is taken and then given back—affect red blood cells in healthy volunteers. Researchers want to see if there are any noticeable changes in the blood before and after the transfusion, especially looking for specific markers that could indicate if someone is using this method to enhance athletic performance, which is considered doping.

To participate in this study, you need to be a healthy male between the ages of 18 and 35 who is physically active and not currently competing in sports. You should not have any health issues that require regular medication or that would prevent you from exercising. If you join, you’ll have a blood sample taken before and after the transfusion, and the researchers will analyze these samples to look for changes. This trial is important because it could help identify ways to detect if athletes are using autologous blood transfusions to gain an unfair advantage in sports.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Male between 18 and 35 years old
• • Without health problem nor disease requiring regular medical treatment
• • Free from any intercurrent acute pathology over 7 days
• • Healthy volunteers who have regularly sport activity, able to have blood sample and is out-of-competition during the research
• • Subject who did not practice a competition (or exhaustive training ) 3 days before the blood sample and the autotransfusion
• • Affiliated to a social security regimen
• Exclusion Criteria:
• • Subject with contraindication for drawing blood
• • Subject with medical pathology contraindicating sport practice
• • Subject under treatments or drugs in the list of products prohibited for sports practice and competitions, in particular erythropoeitins and erythropoiesis-stimulating agents (updated list of World Anti-Doping Agency https://www.wada-ama.org/fr/liste-des-restrictions).
• • Subject with physical or mental disability or restriction of liberty that would prevent autotransfusion
• • Subject without a social security regimen
• • Subject under guardianship or curatorship
• • Subject participating in any Interventional study
• • Positive HIV and/or hepatitis serology
• • Discovery of a hematological disease