Biomarkers of Acute Stroke in Clinic

Launched by ISCHEMIA CARE LLC · Mar 29, 2019

Keywords

ClinConnect Summary

This clinical trial is studying a test called ISCDX, which aims to help doctors understand the different causes of strokes. Strokes can happen for various reasons, and the trial focuses on two specific types: cardioembolic strokes, which are caused by blood clots that travel from the heart, and large artery atherosclerotic strokes, which occur due to blockages in the major arteries. The goal is to see if the ISCDX test can accurately tell the difference between these types of strokes, especially when the cause is not immediately clear.

To participate in this trial, individuals must be between the ages of 18 and 80 and show signs of an acute ischemic stroke (a type of stroke where blood flow to the brain is blocked). They should arrive at the emergency department within 30 hours of when their symptoms began. Participants will be required to provide informed consent and undergo some tests, including brain scans, to make sure they do not have other medical issues that could interfere with the study. This trial is currently looking for participants and aims to improve how doctors diagnose and treat strokes in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients \>18 and \< 80 years of age.
• • Signs and symptoms suggestive of AIS due to cardioembolic, large vessel, or unknown etiology according to TOAST criteria.
• • Arrival to the ED within 30 hours of symptom onset or last known normal time and clinical evidence suggesting Acute Ischemic Stroke.
• • Head CT or MRI ruling out other pathology such as vascular malformation, hemorrhage, tumor or abscess which would likely be responsible for presenting neurologic symptoms
• • Informed consent obtained
• Exclusion Criteria:
• • Any central nervous system infection, i.e. meningitis or encephalitis in the past 30 days
• • Any form of head trauma, stroke or intracranial hemorrhage in the past 30 days
• • Any history of primary or metastatic brain cancer
• • Active cancer defined as a diagnosis of cancer, within 6 months before enrollment, any treatment for cancer within the previous 6 months, or recurrent or metastatic cancer.
• • Autoimmune diseases: such as lupus, rheumatoid arthritis, Crohn's disease, ulcerative colitis
• • Active chronic infectious diseases (eg. HIV/AIDS, hepatitis C)
• • Any underlying medical condition which in the opinion of the investigator would prohibit the patient from providing informed consent
• • Major surgery within three months prior to the index event
• • Signs and symptoms suggestive of (i) AIS due to small vessel occlusion (lacune) and other known etiology according to TOAST criteria, as well as (ii) stroke mimics, transient ischemic attacks, or transient neurological events.