Low Energy Diet and Familial Partial Lipodystrophy

Launched by CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST · Apr 1, 2019

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a low energy diet (LED) on people with familial partial lipodystrophy, a condition that affects how the body stores fat, and diabetes. Participants will follow a strict diet for 12 weeks, during which they will replace their usual meals with specially designed food to help manage their condition. After this initial period, they will gradually reintroduce regular foods. The researchers will monitor participants' health and how well their bodies respond to insulin for a full year. To gain deeper insights into the changes happening in their bodies, some participants may also provide small samples of fat and muscle tissue for analysis.

To be eligible for this trial, participants must be at least 18 years old, have familial partial lipodystrophy, and have type 2 diabetes that is being managed but not completely controlled. They should be stable in weight for the past three months and willing to check their blood sugar levels daily. However, individuals who are pregnant, have untreated thyroid issues, or have a history of eating disorders are not eligible. This study not only aims to improve understanding of how diet can affect insulin sensitivity but also hopes to find effective dietary strategies for managing these complex conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Familial Partial Lipodystrophy
• • Age \>= 18 yrs
• • T2DM
• • Willingness to check daily blood sugars
• • HbA1c between 53mmol(7%)- 108 mmol(12%)
• • Weight stable for 3 months
• • Capacity to consent
• Exclusion Criteria:
• • Pregnancy
• • Untreated thyroid dysfunction (patients who have been euthyroid on medication for at least 3 months can be included)
• • Use of medication adversely that affects diabetes control (e.g. steroids/ immunosuppressants/ certain antipsychotics)
• • Incapacity to give informed consent
• • History of an eating disorder/ purging behaviour
• • Previous gastric bypass/ banding
• • Use of Leptin Therapy
• • Untreated retinopathy