Volume Support/Assist Control Mode Ventilation and Diaphragmatic Atrophy

Launched by UNIVERSITY OF CHICAGO · Apr 1, 2019

Keywords

ClinConnect Summary

This clinical trial is studying two different ways of helping patients breathe when they are on a machine called a ventilator. The goal is to see how these methods, known as controlled mode ventilation and support mode ventilation, affect how long patients can breathe on their own after being on the ventilator and whether they experience a condition called diaphragmatic atrophy, which is when the diaphragm muscle weakens from not being used enough.

To be part of this study, participants need to be at least 18 years old and have been on a ventilator for less than 36 hours. However, certain people are not eligible, including those who are pregnant, have had a recent lung emergency, or have specific muscle or nerve issues. If you join the trial, you will receive one of the two breathing support methods, and the research team will monitor your recovery process closely. This study is currently looking for participants, so if you or your family member might qualify, it could be a valuable opportunity to contribute to important medical research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • subjects \> 18 years of age that have been intubated and mechanically ventilated for \< 36 hours at the time of screening will be eligible for enrollment
• Exclusion Criteria:
• • 1. pregnancy
• • 2. cardiopulmonary arrest
• • 3. history of diaphragmatic paralysis or neuromuscular disease
• • 4. chronic obstructive pulmonary disease (COPD) or asthma exacerbation with evidence of auto-PEEPing requiring intubation
• • 5. neuromuscular blockade
• • 6. expectation to be liberated from ventilator in \< 24 hours
• • 7. history of mechanical ventilation in the last 6 months
• • 8. presence of tracheostomy
• • 9. high cervical spine injury