Crystalline Glucosamine Sulfate Therapy in Hand Osteoarthritis

Launched by UNIVERSITY OF SIENA · Apr 9, 2019

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Eligibility criteria

• Inclusion Criteria:
• • Mono or bilateral primary HOA and concomitant knee OA, according to the American College of Rheumatology (ACR) criteria
• • Treatment for at least 6 consecutive months with crystalline GS at the daily dose of 1500 mg in addition to the conventional therapy or with usual care alone.
• • HOA symptoms duration for at least 3 months defined as global hand pain score superior to 40 mm on a 0-100 VAS and a FIHOA score of at least 6.
• • Radiographic evidence of HOA within the previous 6 months with a radiological score of II-III (using the Kellgren method).
• Exclusion Criteria:
• • Erosive Osteoarthritis of the hand
• • Medical history of any inflammatory joint disease, septic arthritis, previous articular fracture of the concerned joints, monarticular post-traumatic OA of the finger, a history or the presence of any other rheumatic diseases that could cause secondary OA, such as hemochromatosis.
• • Ongoing therapy with opioid analgesics and any kind of topical treatment
• • Therapy with SYSADOAs other than GS, steroids by any route of administration and intra-articular injection of any joint with hyaluronic acid during the previous 6 months.
• • Contraindications or special warnings for GS presented in the data sheet.