The Membrane Adsorbing OXiris Filter in Septic Patients With AKI

Launched by FRANCO TURANI · Apr 12, 2019

Keywords

ClinConnect Summary

Patients with a diagnosis of sepsis or septic shock Gram + , Gram - and acute renal failure All patients are submitted to Continuous Renal Replacement Therapy with the treated heparin-coated membrane (oXiris;Baxter );

* Citrate Anticoagulation or Heparin with thromboelasthograpy monitoring .
* Hemodynamic monitoring with dynamic parameters ( Cardiac Index ,Stroke Volume Variation , Pulse Pressure Variation ) and Echocardiography
* Indirect Calorimetry ( before Continuous Renal Replacement Therapy and after 1 hour stopping Continuous Renal Replacement Therapy )
* Laboratory: white blood cel...

Gender

ALL

Eligibility criteria

• • Inclusion Criteria:- Age \<18 years 75 years \>
• • Diagnosis of sepsis or septic shock (Sepsis III)
• • Mechanical Ventilation or non Invasive ventilation with PaO2 /FIO2 \< 200.
• • Renal failure ( AKI ≥ 1)
• • Endotoxin ( EAA ) : EAA ≥ 0.6 -0.9 \> or IL6 \> 150 pg/mL
• Exclusion Criteria:
• • Pregnancy;
• • Age \< 18 years 75\>
• • Chronic Renal failure or previous CRRT
• • Immunological disease or immunosuppressive drugs or EAA \< 0.6 with IL 6 in the normal range.
• • CGS \< 8 due to hemorrhagic or ischemic event.
• • ECMO v-v or a-v or ECCO2 removal.
• • No resolution of the surgical source of infection
• • Terminal condition
• • Any contraindication to heparin and other anticoagulant.
• • Other pathological conditions in which the oXiris filter is not indicated and other therapeutic options are required. (eg . Hepatic failure , Cardiac failure )