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Search / Trial NCT03915964

A Study of Baricitinib (LY3009104) in Participants With Rheumatoid Arthritis

Launched by ELI LILLY AND COMPANY · Apr 12, 2019

Trial Information

Current as of April 25, 2025

Active, not recruiting

Keywords

ClinConnect Summary

This clinical trial is looking at a medication called baricitinib to see how safe it is compared to another type of drug known as TNF inhibitors for people with rheumatoid arthritis. The main focus is to understand if using baricitinib affects the risk of blood clots in the veins, which can be a serious health concern. This study is currently active but not recruiting new participants.

To be part of this trial, individuals should be between 50 and 74 years old, have a documented history of blood clots, or have certain weight-related health concerns. They should also have not responded well to or cannot tolerate at least one other arthritis treatment. However, participants cannot be pregnant, have certain serious health conditions, or have had recent vaccinations. If eligible, participants can expect to receive careful monitoring and support throughout the study to ensure their safety and well-being.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • * Participants must have at least one of the following characteristics:
  • Documented evidence of a VTE prior to this study
  • At least 60 years of age
  • A body mass index (BMI) greater than or equal to 30 kilograms per meter squared (kg/m²), or
  • Age 50 to less than 60 years and BMI 25 to less than 30 kg/m².
  • Participants must have an inadequate response or intolerance to at least 1 disease-modifying antirheumatic drugs (DMARD) (synthetic or biologic).
  • Exclusion Criteria:
  • Participant should have no reason to not take a TNF inhibitor.
  • Participants must not be pregnant or breastfeeding.
  • Participants must not have had more than one VTE.
  • Participants must not have cancer.
  • Participants must not have active herpes zoster, serious infection, active tuberculosis, or any other serious illness.
  • Participants must not have had a live vaccine within four weeks of study start.
  • Participants must not have participated in any other clinical trial within four weeks of study start.
  • Participants must not have a history of IV drug use, other illicit drug abuse, or chronic alcohol abuse in the past year.

About Eli Lilly And Company

Eli Lilly and Company is a global healthcare leader dedicated to creating innovative medicines that improve patient outcomes across a range of therapeutic areas, including diabetes, oncology, immunology, and neurodegenerative diseases. With a rich history of scientific research and a commitment to advancing healthcare, Lilly invests significantly in clinical trials to develop new treatments and enhance existing therapies. The company prioritizes patient safety and ethical standards in its clinical research, fostering collaboration with healthcare professionals and stakeholders to ensure the delivery of high-quality, evidence-based solutions that address unmet medical needs worldwide.

Locations

Lebanon, New Hampshire, United States

Oklahoma City, Oklahoma, United States

Lebanon, New Hampshire, United States

Madrid, , Spain

Madrid, , Spain

Pretoria, , South Africa

Columbus, Ohio, United States

Duncansville, Pennsylvania, United States

Rancho Mirage, California, United States

Haifa, , Israel

Barcelona, , Spain

Elizabethtown, Kentucky, United States

Marietta, Ohio, United States

Wheaton, Maryland, United States

Palm Desert, California, United States

Hull, , United Kingdom

Oklahoma City, Oklahoma, United States

Elche, Alicante, Spain

Brussels, , Belgium

Cordoba, , Spain

New Port Richey, Florida, United States

Sevilla, , Spain

Wolverhampton, , United Kingdom

Stamford, Connecticut, United States

Spokane, Washington, United States

Bethlehem, Pennsylvania, United States

Salisbury, North Carolina, United States

Wilmington, North Carolina, United States

Vigo, Pontevedra, Spain

Naples, Florida, United States

Boise, Idaho, United States

Lincoln, Nebraska, United States

Omaha, Nebraska, United States

Praha 4, , Czechia

Praha 4, , Czechia

San Juan, , Puerto Rico

Elche, Alicante, Spain

Gainesville, Georgia, United States

Middleburg Heights, Ohio, United States

Albuquerque, New Mexico, United States

Atlanta, Georgia, United States

San Antonio, Texas, United States

Wilmington, North Carolina, United States

Torino, , Italy

Torquay, Devon, United Kingdom

Köln, Nordrhein Westfalen, Germany

Vancouver, Washington, United States

Hull, East Yorkshire, United Kingdom

Grand Rapids, Michigan, United States

Bloemfontein, Free State, South Africa

Rapid City, South Dakota, United States

Amsterdam, , Netherlands

Majadahonda, Madrid, Spain

Tula, , Russian Federation

Maroochydore, Queensland, Australia

Upland, California, United States

Portsmouth, Hampshire, United Kingdom

Albuquerque, New Mexico, United States

Getafe, Madrid, Spain

Charlotte, North Carolina, United States

Salisbury, North Carolina, United States

Plymouth, Devon, United Kingdom

Firenze, , Italy

Fribourg, , Switzerland

Gdansk, Pomorskie, Poland

Phoenix, Arizona, United States

Hull, East Yorkshire, United Kingdom

Lansing, Michigan, United States

Kalispell, Montana, United States

Wyomissing, Pennsylvania, United States

Ryazan, , Russian Federation

Miami, Florida, United States

Middleburg Heights, Ohio, United States

Tel Aviv, , Israel

Debrecen, , Hungary

Sydney, New South Wales, Australia

Kfar Saba, , Israel

Istanbul, , Turkey

Maroochydore, Queensland, Australia

Chelmsford, Essex, United Kingdom

Stellenbosch, , South Africa

Hobart, Tasmania, Australia

Camberwell, Victoria, Australia

Sheffield, , United Kingdom

Houston, Texas, United States

New Port Richey, Florida, United States

Nadarzyn, Mazowieckie, Poland

Wien, , Austria

Leland, North Carolina, United States

Houston, Texas, United States

Dudley, West Midlands, United Kingdom

Glendale, Arizona, United States

Wyomissing, Pennsylvania, United States

League City, Texas, United States

Merksem, Vlaams Gewest, Belgium

Genk, , Belgium

Praha 2, Praha, Hlavní Mešto, Czechia

Brno, , Czechia

Ostrava, , Czechia

Zlin, , Czechia

Würzburg, Bayern, Germany

Dresden, Sachsen, Germany

Kifissia, Attiki, Greece

Budapest, Pest, Hungary

Ashkelon, Hadarom, Israel

Haifa, ḥeifā, Israel

Kaunas, , Lithuania

Siauliai, , Lithuania

Katowice, , Poland

Warszawa, , Poland

Ponce, , Puerto Rico

San Juan, , Puerto Rico

Saint Petersburg, Leningradskaya Oblast', Russian Federation

Ul'yanovsk, Ul'yanovskaya Oblast, Russian Federation

Moscow, , Russian Federation

Partizanske, , Slovakia

Spisska Nova Ves, , Slovakia

Topolcany, , Slovakia

Port Elizabeth, Eastern Cape, South Africa

Durban, Kz Natal, South Africa

Cape Town, Western Cape, South Africa

Stellenbosch, Western Cape, South Africa

London, Surrey, United Kingdom

Newcastle Upon Tyne, Tyneside, United Kingdom

Konya, , Turkey

Tel Aviv, , Israel

Alexandroupolis, , Greece

Wien, , Austria

Chicago, Illinois, United States

Edirne, , Turkey

Wolverhampton, West Midlands, United Kingdom

San Antonio, Texas, United States

Liverpool, , United Kingdom

Paris, , France

Chieti, , Italy

Fullerton, California, United States

Saint Peters, Missouri, United States

Mesa, Arizona, United States

Boca Raton, Florida, United States

Frankfurt Am Main, Hessen, Germany

Caluire Et Cuire, , France

Eskisehir, , Turkey

Truro, England, United Kingdom

South Miami, Florida, United States

Budapest, , Hungary

Caluire Et Cuire, , France

Poznan, , Poland

Wichita, Kansas, United States

Freiburg Im Breisgau, Baden Württemberg, Germany

Boise, Idaho, United States

Oklahoma City, Oklahoma, United States

Nice, Alpes Maritimes, France

Tampa, Florida, United States

Reno, Nevada, United States

Praha 4 Nusle, , Czechia

Cincinnati, Ohio, United States

South Charleston, West Virginia, United States

Liege, , Belgium

Fullerton, California, United States

Ankara, , Turkey

Nowa Sol, , Poland

Fall River, Massachusetts, United States

Plantation, Florida, United States

Houston, Texas, United States

Moscow, , Russian Federation

Wichita, Kansas, United States

San Diego, California, United States

Bad Doberan, Mecklenburg Vorpommern, Germany

Miami, Florida, United States

A Coruña, , Spain

Peoria, Arizona, United States

Sevilla, , Spain

Whittier, California, United States

Prague, , Czechia

Evansville, Indiana, United States

Bloemfontein, Free State, South Africa

Silkeborg, Midtjylland, Denmark

Haifa, , Israel

Durham, North Carolina, United States

Bydgoszcz, Kujawsko Pomorskie, Poland

Petrozavodsk, , Russian Federation

Bucuresti, , Romania

St. Gallen, Sankt Gallen, Switzerland

Villajoyosa, Alicante, Spain

Praha, Praha 10, Czechia

Poznan, Wielkopolskie, Poland

San Juan, , Puerto Rico

San Juan, , Puerto Rico

Whittier, California, United States

Baytown, Texas, United States

Wien, , Austria

Pardubice, , Czechia

Berlin, , Germany

Thessaloniki, , Greece

Veszprem, Veszprém City, Hungary

Leeuwarden, Fryslân, Netherlands

St.Gallen, Sankt Gallen, Switzerland

Tucson, Arizona, United States

Covina, California, United States

Nowa Sol, Lubuskie, Poland

Elblag, Warminsko Mazurki, Poland

Bucureti, , Romania

Pinelands, Western Cape, South Africa

Fuenlabrada, Madrid, Spain

Lake Charles, Louisiana, United States

Barcelona, , Spain

Springfield, Missouri, United States

Sutton In Ashfield, Nottinghamshire, United Kingdom

Wels, Oberösterreich, Austria

Fullerton, California, United States

Botany, New South Wales, Australia

Brno, , Czechia

Brasov, Brașov, Romania

Miami, Florida, United States

Ramat Gan, Hamerkaz, Israel

Flagstaff, Arizona, United States

Gilbert, Arizona, United States

Mesa, Arizona, United States

Peoria, Arizona, United States

Huntington Beach, California, United States

Irvine, California, United States

San Leandro, California, United States

Tujunga, California, United States

Tustin, California, United States

Van Nuys, California, United States

Evansville, Indiana, United States

Brighton, Michigan, United States

Santa Fe, New Mexico, United States

Hickory, North Carolina, United States

Rapid City, South Dakota, United States

College Station, Texas, United States

Houston, Texas, United States

Houston, Texas, United States

Houston, Texas, United States

San Antonio, Texas, United States

Sugar Land, Texas, United States

Tomball, Texas, United States

Newcastle, New South Wales, Australia

Wien, , Austria

Charleroi, Hainaut, Belgium

Brno, Brno Zidonice, Czechia

Praha 4, Czech Republic, Czechia

Uherske Hradiste, Zlínský Kraj, Czechia

Brno, , Czechia

Ostrava, , Czechia

Praha 11, , Czechia

Svendborg, , Denmark

Nice, Alpes Maritimes, France

Bordeaux, Aquitaine, France

Strasbourg, Bas Rhin, France

Toulouse, Haute Garonne, France

Limoges, Haute Vienne, France

Vendée, La Roche Sur Yon, France

Nantes, Loire Atlantique, France

Loiret, Orléans, France

Clermont Ferrand, Puy De Dôme, France

Lyon, Rhône Alpes, France

Le Mans, Sarthe, France

Amiens, , France

Caluire Et Cuire, , France

échirolles, , France

Corbeil Essonnes, île De France, France

Osnabrück, Lower Saxony, Germany

Ratingen, Nordrhein Westfalen, Germany

Magdeburg, Sachsen Anhalt, Germany

Bad Pyrmont, , Germany

Berlin, , Germany

Hamburg, , Germany

Hamburg, , Germany

Athens, Attica, Greece

Chaidari, , Greece

Miskolc, Borsod Abauj Zemplen, Hungary

Debrecen, Hajdu Bihar, Hungary

Tatabánya, Komarom Esztergom, Hungary

Haifa, ḥeifā, Israel

Rome, Lazio, Italy

Milan, Milano, Italy

Siena, Toscana, Italy

Abruzzo, , Italy

Milano, , Italy

Napoli, , Italy

Verona, , Italy

Kaunas, Kauno Miestas, Lithuania

Klaipeda, Klaipėdos Miestas, Lithuania

Vilnius, , Lithuania

Beek, Limburg, Netherlands

Rotterdam, Zuid Holland, Netherlands

Rotterdam, Zuid Holland, Netherlands

Torun, Kujawsko Pomorskie, Poland

Warszawa, Mazowieckie, Poland

Warszawa, Mazowieckie, Poland

Warszawa, Mazowieckie, Poland

Bialystok, Podlaskie, Poland

Poznan, Wielkopolskie, Poland

Tomaszów Lubelski, , Poland

Ustron, , Poland

Warszawa, , Poland

Bytom, śląskie, Poland

Caguas, , Puerto Rico

Braila, Brăila, Romania

Iasi, Iași, Romania

Baia Mare, Maramures, Romania

Bucuresti, Sector 1, Romania

Râmnicu Vâlcea, Valcea, Romania

Galati, , Romania

Kursk, Kurskaya Oblast, Russian Federation

Moscow, Moskovskaya Oblast, Russian Federation

Moscow, Moskva, Russian Federation

Nizhny Novgorod, Nizhegorodskaya Oblast, Russian Federation

Saint Petersburg, Sankt Peterburg, Russian Federation

St. Petersburg, Sankt Peterburg, Russian Federation

Yaroslavl, Yaroslavskaya Oblast', Russian Federation

Saratov, , Russian Federation

Zvolen, Banskobystrický Kraj, Slovakia

Bratislava, Bratislavský Kraj, Slovakia

Kosice, , Slovakia

Univ Of Free State, Bloemfontein, South Africa

Kempton Park, Gauteng, South Africa

Soweto, Gauteng, South Africa

Durban, Kwazulu Natal, South Africa

Umhlanga, Kwazulu Natal, South Africa

Barcelona, Catalunya, Spain

Sabadell, Catalunya, Spain

Sant Joan Despí, Catalunya, Spain

Santiago De Compostela, La Coruna, Spain

Bilbo, País Vasco, Spain

Córdoba, , Spain

La Coruña, , Spain

Basel, Basel Stad, Switzerland

Ankara, , Turkey

İstanbul, , Turkey

Izmir, , Turkey

Truro, Cornwall, United Kingdom

Christchurch, Dorset, United Kingdom

London, Hampstead, United Kingdom

Sutton In Ashfield, Nottinghamshire, United Kingdom

Santiago De Compostela, A Coruña [La Coruña], Spain

Covina, California, United States

Houston, Texas, United States

Santiago De Compostela, Galicia [Galicia], Spain

Springfield, Missouri, United States

Chaidari, Attikí, Greece

Siena, Toscana, Italy

Chicago, Illinois, United States

Ostrava, Ostrava Město, Czechia

Napoli, , Italy

Peoria, Arizona, United States

Warszawa, Mazowieckie, Poland

Vienna, Wien, Austria

Tula, Tul'skaya Oblast', Russian Federation

Brussels, Bruxelles Capitale, Région De, Belgium

Miskolc, Borsod Abaúj Zemplén, Hungary

Ponce, , Puerto Rico

Torun, Kujawsko Pomorskie, Poland

Ryazan, Ryazanskaya Oblast', Russian Federation

Tucson, Arizona, United States

Huntington Beach, California, United States

Brno, Brno Město, Czechia

Ostrava, Moravskoslezský Kraj, Czechia

La Roche Sur Yon, Vendée, France

Tel Aviv, Tell Abīb, Israel

Barcelona, Catalunya [Cataluña], Spain

Istanbul, , Turkey

A Coruña, A Coruña [La Coruña], Spain

Strasbourg, Alsace, France

Paris, , France

Getafe, Madrid, Comunidad De, Spain

Covina, California, United States

Tomball, Texas, United States

Whittier, California, United States

Vandoeuvre Lès Nancy, Meurthe Et Moselle, France

Konya, , Turkey

Köln, Nordrhein Westfalen, Germany

A Coruña, A Coruña [La Coruña], Spain

Alexanroupolis, évros, Greece

Warszawa, Mazowieckie, Poland

Orléans, Centre, France

Konya, , Turkey

Majadahonda, Madrid, Comunidad De, Spain

Charlotte, North Carolina, United States

Bucharest, București, Romania

Eskisehir, Eskişehir, Turkey

Bordeaux, Aquitaine, France

Bad Doberan, Mecklenburg Vorpommern, Germany

Newcastle Upon Tyne, North Tyneside, United Kingdom

Chatsworth, Kwazulu Natal, South Africa

Debrecen, , Hungary

Katowice, śląskie, Poland

Hull, Kingston Upon Hull, United Kingdom

Bydgoszcz, Kujawsko Pomorskie, Poland

Warszawa, Mazowieckie, Poland

Budapest, Pest, Hungary

Budapest, , Hungary

Köln, Nordrhein Westfalen, Germany

Bucuresti, București, Romania

Moscow, Moskva, Russian Federation

Dudley, England, United Kingdom

Plymouth, Devon, United Kingdom

Warszawa, Mazowieckie, Poland

Bucharest, București, Romania

Izmir, , Turkey

Thessaloniki, Kentrikí Makedonía, Greece

Bytom, śląskie, Poland

Palm Desert, California, United States

Vienna, Wien, Austria

Praha 4, Czech Republic, Czechia

Frankfurt Am Main, Hessen, Germany

Hamburg, , Germany

Chieti, Abruzzo, Italy

Siauliai, , Lithuania

Born, Limburg, Netherlands

Bucuresti, Sector 1, Romania

Saint Petersburg, Sankt Peterburg, Russian Federation

St. Petersburg, Sankt Peterburg, Russian Federation

Moscow, , Russian Federation

Saratov, , Russian Federation

Univ Of Free State, Bloemfontein, South Africa

Pretoria, Gauteng, South Africa

Chatsworth, Kwazulu Natal, South Africa

Umhlanga, Kwazulu Natal, South Africa

Sabadell, Catalunya, Spain

Fuenlabrada, Madrid, Spain

Vigo, Pontevedra, Spain

A Coruña [La Coruña], , Spain

A Coruña, , Spain

Basel, Basel Stad, Switzerland

İstanbul, , Turkey

London, Surrey, United Kingdom

London, England, United Kingdom

South Charleston, West Virginia, United States

Genk, Limburg, Belgium

Brno, Brno Město, Czechia

Brno, Brno Město, Czechia

Brno, Jihomoravský Kraj, Czechia

Pardubice, Pardubický Kraj, Czechia

Zlin, Zlínský Kraj, Czechia

Praha 4, , Czechia

Svendborg, Syddanmark, Denmark

Frankfurt, Hessen, Germany

Alexandroupolis, évros, Greece

Tomaszów Lubelski, Lubelskie, Poland

Poznan, Wielkopolskie, Poland

Ustron, śląskie, Poland

Bucuresti, București, Romania

Moscow, Moskva, Russian Federation

Ryazan, Ryazanskaya Oblast, Russian Federation

Kosice, Košický Kraj, Slovakia

Spisska Nova Ves, Košický Kraj, Slovakia

Topolcany, Nitriansky Kraj, Slovakia

Partizanske, Trenčiansky Kraj, Slovakia

Barcelona, Catalunya [Cataluña], Spain

Barcelona, Catalunya [Cataluña], Spain

Sabadell, Catalunya [Cataluña], Spain

Sant Joan Despí, Catalunya [Cataluña], Spain

Fuenlabrada, Madrid, Comunidad De, Spain

Vigo, Pontevedra [Pontevedra], Spain

Basel, Basel Stad, Switzerland

Christchurch, Bournemouth, United Kingdom

London, Waltham Forest, United Kingdom

South Charleston, West Virginia, United States

Budapest, Pest, Hungary

Sabadell, Catalunya [Cataluña], Spain

Okemos, Michigan, United States

Houston, Texas, United States

Tustin, California, United States

Brno, Jihomoravský Kraj, Czechia

Praha, Praha 4, Czechia

Zlín, Zlínský Kraj, Czechia

Lille, , France

Haifa, ḥeifā, Israel

Siauliai, šiauliai, Lithuania

Elblag, Warmińsko Mazurskie, Poland

Galati, Galați, Romania

Baia Mare, Maramureș, Romania

Râmnicu Vâlcea, Vâlcea, Romania

Kursk, Kurskaya Oblast', Russian Federation

Moscow, Moskovskaya Oblast', Russian Federation

Nizhny Novgorod, Nizhegorodskaya Oblast', Russian Federation

Saint Petersburg, Sankt Peterburg, Russian Federation

Ulianovsk, Ul'yanovskaya Oblast', Russian Federation

Yaroslavl, , Russian Federation

Cordoba, Córdoba, Spain

Basel, Basel Stadt, Switzerland

Stanbul, İstanbul, Turkey

Houston, Texas, United States

Charleston, West Virginia, United States

Poznan, Wielkopolskie, Poland

Patients applied

0 patients applied

Trial Officials

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)

Study Director

Eli Lilly and Company

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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