Use of Methoxyflurane (Penthrox) as an Antalgic in Hospital Trauma
Launched by UNIVERSITY HOSPITAL, TOURS · Apr 23, 2019
Trial Information
Current as of July 25, 2025
Completed
Keywords
ClinConnect Summary
Intra-hospital, the prevalence of pain is major; this is variable depending on the studies, but permanently above 60%. A study conducted in 2015 in Tours Adult Emergencies showed a prevalence of pain of 66.5% with an average waiting time of 2h28 before receiving an analgesic.
The pain management protocol at the Tours emergency department includes paracetamol for a numerical evaluation scale (EN) \< 3 and tramadol for an EN between 4 and 6. But these therapies have a delay of action too long or are given too late. An improvement in the management of pain in emergency is therefore necessary....
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Conscious patient
- • Age ≥ 18 years
- • Acute pain of monotraumatic origin
- • Pain \> 4 on a visual numerical scale
- Exclusion Criteria:
- • State of shock with unstable hemodynamics (PA \<90/60)
- • Suspected or proven trauma to the chest, abdomen or pelvis
- • Serious head trauma
- • Consciousness disorder with Glasgow score \<15
- • Patient who has already received analgesics (with the exception of paracetamol)
- • Patient receiving an intravenous approach for analgesia
- • Renal or hepatic disorders known
- • Hypersensitivity to fluoridated anesthetics or history of malignant hyperthermia in the patient or family
- • Pregnant or nursing woman
- • Patient under judicial protection
- • Non communicating patient or with difficulties of understanding
- Exclusion Criteria:
- • Intravenous injection for analgesia
About University Hospital, Tours
The University Hospital of Tours, a leading academic medical institution in France, is dedicated to advancing healthcare through innovative clinical research and patient-centered care. With a strong emphasis on collaboration between researchers, clinicians, and community partners, the hospital fosters a dynamic environment for conducting high-quality clinical trials across various medical disciplines. Its commitment to excellence in patient safety, ethical standards, and scientific integrity positions the University Hospital of Tours as a pivotal contributor to the development of new therapies and health solutions, ultimately enhancing patient outcomes and public health.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Tours, , France
Patients applied
Trial Officials
Julien CONRAS, MD
Principal Investigator
University Hospital, Tours
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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