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Search / Trial NCT03927729

Use of Methoxyflurane (Penthrox) as an Antalgic in Hospital Trauma

Launched by UNIVERSITY HOSPITAL, TOURS · Apr 23, 2019

Trial Information

Current as of July 25, 2025

Completed

Keywords

Methoxyflurane Penthrox Non Opioid Analgesia Traumatic Pain Pain Antalgic Protocol Emergency Department

ClinConnect Summary

Intra-hospital, the prevalence of pain is major; this is variable depending on the studies, but permanently above 60%. A study conducted in 2015 in Tours Adult Emergencies showed a prevalence of pain of 66.5% with an average waiting time of 2h28 before receiving an analgesic.

The pain management protocol at the Tours emergency department includes paracetamol for a numerical evaluation scale (EN) \< 3 and tramadol for an EN between 4 and 6. But these therapies have a delay of action too long or are given too late. An improvement in the management of pain in emergency is therefore necessary....

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Conscious patient
  • Age ≥ 18 years
  • Acute pain of monotraumatic origin
  • Pain \> 4 on a visual numerical scale
  • Exclusion Criteria:
  • State of shock with unstable hemodynamics (PA \<90/60)
  • Suspected or proven trauma to the chest, abdomen or pelvis
  • Serious head trauma
  • Consciousness disorder with Glasgow score \<15
  • Patient who has already received analgesics (with the exception of paracetamol)
  • Patient receiving an intravenous approach for analgesia
  • Renal or hepatic disorders known
  • Hypersensitivity to fluoridated anesthetics or history of malignant hyperthermia in the patient or family
  • Pregnant or nursing woman
  • Patient under judicial protection
  • Non communicating patient or with difficulties of understanding
  • Exclusion Criteria:
  • Intravenous injection for analgesia

About University Hospital, Tours

The University Hospital of Tours, a leading academic medical institution in France, is dedicated to advancing healthcare through innovative clinical research and patient-centered care. With a strong emphasis on collaboration between researchers, clinicians, and community partners, the hospital fosters a dynamic environment for conducting high-quality clinical trials across various medical disciplines. Its commitment to excellence in patient safety, ethical standards, and scientific integrity positions the University Hospital of Tours as a pivotal contributor to the development of new therapies and health solutions, ultimately enhancing patient outcomes and public health.

Locations

Tours, , France

Patients applied

0 patients applied

Trial Officials

Julien CONRAS, MD

Principal Investigator

University Hospital, Tours

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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