Gene Expression Changes In Young and Geriatric Skin

Launched by WRIGHT STATE UNIVERSITY · Apr 26, 2019

Keywords

ClinConnect Summary

This clinical trial is studying how the skin of young adults and older adults reacts to artificial sunlight, specifically ultraviolet B (UVB) rays, which are the rays that can cause sunburn. Researchers want to understand why older skin seems to respond differently to UVB compared to younger skin. They believe that a protein called insulin-like growth factor-1 (IGF-1) is more abundant in young skin and may play a role in this difference. By injecting a small amount of IGF-1 into older skin, the researchers hope to see if it can help older skin react more like younger skin when exposed to UVB.

To participate in this study, you would need to be either a young adult (ages 21-30) or a geriatric adult (65 and older) with fair skin. It's important that you don’t have certain health conditions, like diabetes or skin allergies, and that you are not currently taking medications that make your skin sensitive to sunlight. If you join the study, you can expect to have your skin's response to UVB tested and monitored, helping researchers learn more about how to protect skin and possibly reduce the risk of skin cancer in older adults.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male/Female
• • White skin (Fitzpatrick types I and II)
• • Age 21-30 or 65 and older
• • Able to comprehend procedures/risks
• Exclusion Criteria:
• • Known photosensitivity
• • Currently on photosensitizing medications
• • Diabetes Mellitus
• • History of abnormal scarring
• • History of skin infections
• • Known allergy to lidocaine local anesthetic
• • Pregnancy or nursing
• • Other serious health issues