Characterization of the Microbiome in Cutaneous T Cell Lymphoma

Launched by NORTHWESTERN UNIVERSITY · Apr 28, 2019

Keywords

ClinConnect Summary

This clinical trial is studying the microbiome in patients with cutaneous T cell lymphoma, which is a type of cancer that affects the skin. The researchers want to understand how the bacteria and other microorganisms living on the skin of these patients differ from those of healthy individuals who are similar in age and gender. By comparing these two groups, the study hopes to uncover important information that could help in understanding this disease better.

To participate in the trial, you need to be between 18 and 89 years old and fit certain criteria. This includes having specific stages of cutaneous T cell lymphoma or certain other skin conditions, like psoriasis or atopic dermatitis. Healthy individuals without these conditions can also join. Participants will provide consent and may undergo assessments to collect samples for the study. It's important to note that those who are currently on antibiotics or cannot give consent are not eligible to join. This research could lead to valuable insights into how skin health and immune responses are linked in people with skin cancers.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Group 1: Patients with stage IA-IIA cutaneous T cell lymphoma
• • Group 2: Patients with stage IIB and above cutaneous T cell lymphoma
• • Group 3: Patients with CD30+ lymphoproliferative disorder including lymphomatoid papulosis and cutaneous anaplastic large cell lymphoma
• • Group 4: Patients with plaque psoriasis with BSA\>5% on routine phototherapy per standard of care
• • Group 5: Patients with moderate to severe atopic dermatitis on routine bleach bath therapy per standard of care
• • Group 6: Healthy individuals without the above skin conditions, similar age and sex distribution to the patients with cutaneous T cell lymphoma
• • All Groups: subjects who are age 18-89 years of age at time of enrollment
• • All Groups: Subjects who are able and willing to give informed consent for this study and the Dermatology Tissue Acquisition and Biorepository (STU00009443).
• Exclusion Criteria:
• • All Groups: Subjects who are younger than 18 years of age or older than 90 years of age
• • All Groups: Subjects who are unable to give consent
• • Patients currently on systemic antibiotics or recent (within past 4 weeks) exposure to systemic antibiotics
• • We will not recruit the following populations: adults unable to consent, individuals who are not yet adults (infants, children, teenagers), pregnant women, prisoners and other vulnerable populations.