STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon

Launched by UNIVERSITY OF PITTSBURGH · Apr 29, 2019

Keywords

ClinConnect Summary

The STABILITY 2 trial is studying the best ways to perform surgery for young people who have torn their anterior cruciate ligament (ACL), a common injury in athletes. The trial will compare two types of surgical grafts—bone-patellar-tendon-bone (BPTB) and quadriceps tendon (QT)—and whether adding an extra procedure called lateral tenodesis (LET) can help prevent re-injury. The goal is to find the most effective approach to improve recovery and reduce the risk of future knee problems in active patients aged 14 to 25.

To participate in this trial, individuals need to be between 14 and 25 years old, have a knee injury where the ACL is torn, and be physically active in sports that involve quick movements. They should also have specific knee conditions that indicate a higher risk of re-injury. Participants will randomly be assigned to one of the surgery options and will be closely monitored throughout their recovery. This study is important because it aims to improve long-term outcomes for young athletes who are at risk of re-injuring their knees after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 14-25,
• • An ACL-deficient knee,
• • Skeletal maturity (i.e. closed epiphyseal growth plates on standard knee radiographs),
• • At least two of the following: participate in a competitive pivoting sport; have a pivot shift of grade 2 or greater; have generalized ligamentous laxity (Beighton score of ≥4) and/or genu recurvatum \>10 degrees.
• Exclusion Criteria:
• • Previous ACLR on either knee,
• • Partial ACL injury (defined as one bundle ACL tear requiring reconstruction/augmentation of the torn bundle with no surgery required for the intact bundle),
• • Multiple ligament injury (two or more ligaments requiring surgery),
• • Symptomatic articular cartilage defect requiring treatment other than debridement,
• • \>3 degrees of asymmetric varus,
• • Inflammatory arthropathy,
• • Inability to provide consent,
• • Pregnancy at baseline.