Luteal Support in Frozen-Thawed Embryo Transfer Cycles

Launched by CENTRUM CLINIC IVF CENTER · May 10, 2019

Keywords

ClinConnect Summary

In natural pregnancy, successful implantation and pregnancy necessitates well-functioning corpus luteum. Luteal phase support (LPS) is critical in assisted conception cycles particularly for replacement frozen embryo transfer cycles owing to lack of corpus luteum. 3 different LPS options have been suggested:

* Progesterone in oil (intramuscular injections) is rapidly absorbed after i.m. injection and high progesterone plasma concentrations are reached after approximately 2h. Despite satisfactory plasma levels, the possible side-effects of pain and swelling are limiting the use.
* Vaginal a...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • woman aged 20-40 years
• • Having available blastocyst(s) cryopreserved by vitrification method.
• Exclusion Criteria:
• • requirement for fresh embryo(s);
• • presence of any clinically relevant systemic disease contraindicated for assisted reproduction or pregnancy
• • history of more than three failed cycles of IVF
• • history of recurrent abortions
• • allergy history for relevant drugs
• • body mass index of \<18 or \>38 kg/m2 at screening
• • current breastfeeding or pregnancy
• • refusal or inability to comply with the requirements of the protocol for any reason, including scheduled clinic visits and laboratory tests
• • trophectoderm or blastomere biopsy of the blastocyst(s) to be transferred