Treating Postictal Symptoms Using Ibuprofen and Nifedipine

Launched by UNIVERSITY OF CALGARY · May 10, 2019

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two medications, ibuprofen and nifedipine, on people with epilepsy who experience post-seizure symptoms. After a seizure, some patients may have temporary problems with blood flow to the brain and may feel confused or have other neurological issues. In this study, one group of participants will receive ibuprofen, another group will receive nifedipine, and a third group will receive a placebo (a pill that has no active medication) to see which, if any, helps improve these symptoms.

To be eligible for the trial, participants must be over 16 years old and have frequent seizures, meaning they have more than one seizure per week. They should also be able to complete some cognitive tests. However, individuals with certain medical conditions or who have recently used specific medications will not be included. If you join the trial, you will be closely monitored and may undergo tests to evaluate how well the treatment is working. This research aims to find better ways to help those affected by epilepsy recover after seizures.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age \> 16 yrs, frequent seizures (\>1 per week) and cognitive ability sufficient to complete neuropsychological testing.
• Exclusion Criteria:
• • multiple seizure onset zones, contraindications to CT or MR imaging, any contraindication to ibuprofen or nifedipine, as well as current or recent (\< 2 months) exposure COX-2 inhibitor or calcium channel blocker.