Autologous Platelet Rich Plasma (PRP) Intra Ovarian Infusion in Perimenopausal Women

Launched by GENESIS ATHENS CLINIC · May 14, 2019

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called autologous platelet-rich plasma (PRP) infusion, which involves using a special component from a woman's own blood to potentially improve ovarian function and hormone levels in women who are experiencing changes in their menstrual cycles due to perimenopause. The goal is to see if this treatment can help improve fertility in women over 40 who have irregular menstrual cycles.

To be eligible for this study, participants must be at least 40 years old and have irregular menstrual cycles, which can include having cycles that vary by more than seven days or having very long cycles. Women must also have stopped any other hormonal treatments for at least three months. However, certain conditions, like endometriosis or previous cancers of the reproductive system, would exclude someone from participating. Those who join can expect to follow specific study guidelines and help researchers understand whether this innovative treatment can support women's reproductive health during perimenopause.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Women ≥40 years of age, presenting with cycle irregularities while fulfilling at least one of the respective two criteria: more than seven days difference in menstrual cycle duration between two consecutive cycles OR, presence of a menstrual cycle duration over sixty days and progressive elevation of FSH levels.
• • Discontinuation of any complementary/adjuvant treatment including hormone replacement, acupuncture, and botanotherapy, for at least three months prior to recruitment.
• • Willing to comply with study requirements
• Exclusion Criteria:
• • Any pathological disorder related to reproductive system anatomy
• • Amenorrhea
• • Endometriosis
• • Adenomyosis
• • Fibroids and adhesions
• • Infections in reproductive system
• • Current or previous diagnosis of cancer in reproductive system
• • History of familiar cancer in reproductive system
• • Severe male factor infertility
• • Prior referral for PGT
• • Ovarian inaccessibility
• • Previous POI diagnosis -Endocrinological disorders (Hypothalamus-
• • Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome)
• • BMI\>30 kg/m2 or BMI\<18.5 kg/m2
• • Systematic autoimmune disorders