Oxybutynin for Post-surgical Bladder Pain and Urgency

Launched by UNIVERSITY OF CALIFORNIA, DAVIS · May 13, 2019

Keywords

ClinConnect Summary

This clinical trial is studying the use of a medication called oxybutynin to help relieve bladder pain and urgency that can occur after bladder surgery. The researchers want to find out if using a skin patch (transdermal) to deliver the medication is more effective than taking it by mouth (oral). The goal is to help children aged 4 to 8 who will have bladder surgery and need a catheter afterward, making them eligible for the study.

If your child is selected to participate, they will receive either the skin patch or the oral medication for a set period. It's important to note that children with previous bladder surgeries, certain neurological conditions, or those taking specific medications will not be eligible for the trial. The study is currently recruiting participants, and it aims to provide better treatment options for managing bladder pain and urgency after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients who will undergo bladder surgery that requires an indwelling bladder catheter after surgery.
• • Age Range: Four to 8 years of age are eligible for the study.
• Exclusion Criteria:
• • Patients who have had prior bladder surgery.
• • Patients who have neurologic disease that could impair bladder sensation.
• • Patients who are already taking antimuscarinic or antispasmodic medications.
• • Patients with glaucoma, any neurologic disease, dementia, impaired mentation or disorder of the central nervous system.
• • Patients taking any medication that affects the central nervous system such as antidepressant, anxiolytic or antipsychotic medications.
• • Less than four years of age cannot have the transdermal patch due to fixed dose. Over 8 years of age: less than 5% of our patients, who undergo this surgery, are over 8 years of age and is usually a rare adolescent. Data in an older cohort may confuse the results since they respond differently to bladder surgery due to larger incision and longer hospital stay with a catheter.