Prediction of Malignant Transformation of Oral Leukoplakia Using a MAGE-A-based Immunoscore

Launched by UNIVERSITY OF ERLANGEN-NÜRNBERG MEDICAL SCHOOL · Jun 4, 2019

Keywords

ClinConnect Summary

This clinical trial is studying a new way to predict whether a type of oral condition called oral leukoplakia (which can be a precancerous lesion) will turn into oral squamous cell carcinoma (OSCC), a common form of mouth cancer. Researchers are focusing on a specific marker called MAGE-A, which is found in many cases of OSCC and in a significant number of oral leukoplakia cases that become cancerous. By looking for this marker, the study aims to improve early detection and potentially guide treatment options, including immunotherapy, which helps the immune system fight cancer.

To participate in this study, individuals must be adults between the ages of 18 and 80 who have been diagnosed with oral leukoplakia. Participants will provide biopsies (small tissue samples), and their condition will be monitored for at least three years to see if cancer develops. The study is currently recruiting participants, and anyone interested in taking part will need to provide consent after understanding the details of the trial. This research could lead to better diagnostic tools and treatment options for people with oral leukoplakia.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults, consenting male or female patients
• • Age 18 - 80 years
• • Diagnosis of one or more leukoplakia of the oral cavity
• • including
• • leukoplakia associated wit lichen planus OR
• • leukoplakia associated with diseases of the immune system or immunosuppression OR
• • leukoplakia associated with a malignoma of other sites (except oral cavity) in the anamnesis
• • Existing consent to participation in the study after clarification has been given
• Exclusion Criteria:
• • clinical evidence of invasive carcinoma of the oral cavity OR
• • carcinoma of the oral cavity in the anamnesis OR
• • patients unable to give informed consent OR
• • rejection of the patient