Isoelectric Focusing of Tears in Children With Radiologically Isolated or Clinically Isolated Syndrome

Launched by LILLE CATHOLIC UNIVERSITY · Jun 6, 2019

Keywords

ClinConnect Summary

This clinical trial is looking at how tears from children might help us understand certain conditions related to multiple sclerosis (MS), specifically Clinically Isolated Syndrome (CIS) and Radiologically Isolated Syndrome (RIS). The goal is to see if analyzing these tears can provide valuable insights over time, helping doctors diagnose and monitor these conditions more effectively. The study is currently recruiting children under 18 years old, who either have had a recent episode of CIS or have been found to have brain lesions suggesting MS on an MRI scan, but are not showing symptoms.

To participate, children must have the agreement of their parents or guardians, and they should be covered by social security. Importantly, the study is not looking for children who have active MS or eye infections, or those on specific treatments that suppress the immune system. If eligible, participants will provide tear samples during the study, and their health will be monitored over time. This research could be a significant step in improving our understanding and diagnosis of these conditions in children.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age \< 18 years old
• • informed consent from the child and the parents (at least one of the two legal guardians)
• • child covered by social security
• For the RIS population:
• • asymptomatic child
• • fortuitous discovery of lesions strongly suggesting sclerosis multiple on a Magnetic resonance imaging (MRI) scan
• For the CIS population:
• • - child presenting a CIS in the past three months
• Exclusion Criteria:
• • patient with remitting MS
• • patient with progressive MS
• • patient with eye infection
• • patient under immunosuppressive therapy on the day of inclusion due to the treatment of another disease than MS