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Search / Trial NCT03981107

Compression Only CPR Versus Standard CPR in Out-Of-Hospital Cardiac Arrest - A Randomized Survival Study

Launched by KAROLINSKA INSTITUTET · Jun 7, 2019

Trial Information

Current as of June 26, 2025

Recruiting

Keywords

Cardiopulmonary Resuscitation Chest Compressions Only Cpr Dispatcher Assisted Cpr Cardiac Arrest

ClinConnect Summary

This clinical trial is studying two types of CPR (cardiopulmonary resuscitation) techniques to see which one works better in helping people who have a cardiac arrest outside of a hospital. Specifically, the trial is comparing "Compression Only CPR" (CO-CPR), which focuses solely on chest compressions, to "Standard CPR" (S-CPR), which includes both chest compressions and rescue breaths. The goal is to find out if CO-CPR is as effective or even better than S-CPR when the person giving help has received CPR training.

To participate in this trial, you need to be someone who has witnessed a cardiac arrest (meaning you saw or heard it happen) and has been trained in CPR. People who are 18 years old or younger, or those who have not been trained in CPR, cannot join this study. If you take part, you will be randomly assigned to use either CO-CPR or S-CPR when helping someone in need. This research is important because it could help increase the chances of survival for people experiencing cardiac arrest and improve how bystanders respond during emergencies.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Unconsciousness with no, abnormal or agonal breathing (suspected OHCA)
  • The suspected OHCA is witnessed (seen or heard)
  • Any Bystander at the scene has previous training in CPR
  • Exclusion Criteria:
  • Age 18 or younger
  • Collapse is not witnessed
  • Bystander has never been taught CPR. (These bystanders should be instructed to administer CO-CPR in accordance to guidelines)
  • Asphyxia, i.e. drowning, strangulation, hanging
  • Intoxication or drug overdose
  • Pregnancy
  • Trauma
  • Post randomisation exclusion Criteria from data analysis:
  • Previous decision that CPR should not be initiated i.e. terminal illness or palliative care
  • No Cardiac arrest, other condition (Cases where EMS did not start CPR)

About Karolinska Institutet

Karolinska Institutet is a renowned medical university located in Sweden, recognized for its commitment to advancing healthcare through innovative research and education. As a leading sponsor of clinical trials, the institution focuses on translating scientific discoveries into effective treatments and therapies, emphasizing patient-centered approaches. With a strong emphasis on collaboration and interdisciplinary research, Karolinska Institutet plays a pivotal role in addressing global health challenges and improving patient outcomes, leveraging its extensive network of experts and state-of-the-art facilities to drive clinical advancements.

Locations

Stockholm, , Sweden

Bergamo, , Italy

Patients applied

0 patients applied

Trial Officials

Jacob Hollenberg, MD, PhD

Principal Investigator

Karolinska Institutet, Department of Medicine Solna

Giuseppe Ristagno, MD, PhD

Study Chair

University of Milan

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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