ClinConnect ClinConnect Logo
Search / Trial NCT03988140

Apico-coronal Position of the Implant in Edentulous Diabetics With Implant-retained Overdentures

Launched by PAULISTA UNIVERSITY · Jun 14, 2019

Trial Information

Current as of July 09, 2025

Completed

Keywords

Dental Prosthesis Biological Markers Dental Implants

ClinConnect Summary

Considering the outcomes achieved with implants with machined-collar inserted supracrestally, it would be relevant to investigate whether this therapeutic strategy could be considered as a more effective approach in the rehabilitation with dental implants of individuals with type 2 DM, since these patients may be more disposed to peri-implant changes, both from the point of view of marginal bone remodeling as related to local variations in immunoinflammatory response. Thus, the propose of this split-mouth randomized controlled trial was to compare the impact of crestal level or supracrestal...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • The inclusion criteria included: patients aged between 50 and 80 years old, 2) totally edentulous in the mandible with previous mandibular dentures for at least 6 months and indicated for rehabilitation with overdenture, 3) patients with diabetes had to have had T2DM, diagnosed by a physician, for at least the past 5 years. Such individuals were either under a dietary regimen and/or were using oral hypoglycaemic agents (metformin or glybenclamin).
  • Exclusion Criteria:
  • Exclusion criteria were: 1) pregnancy, 2) lactation, 3) current smoking or ex-smokers, 4) other systemic conditions that could affect bone metabolism (e.g., immunologic disorders), 5) use of anti-inflammatory, immunosuppressive and anti-resorptive medications, 6) patients that required bone grafts before or concomitantly with implant surgery and 7) a history of previous regenerative procedures in the area designated for implant therapy. Patients with major complications of DM (i.e., cardiovascular and peripheral vascular diseases \[ulcers, gangrene, and amputation\], neuropathy, and nephropathy) were also excluded.

About Paulista University

Paulista University is a leading educational institution in Brazil, renowned for its commitment to advancing medical research and clinical practice. With a strong emphasis on innovation and interdisciplinary collaboration, the university conducts a variety of clinical trials aimed at enhancing patient care and contributing to the global body of medical knowledge. Its dedicated research teams, equipped with state-of-the-art facilities, focus on a wide range of therapeutic areas, ensuring rigorous methodologies and adherence to ethical standards. Paulista University's strategic partnerships with healthcare organizations and industry stakeholders further bolster its capacity to deliver impactful research outcomes that benefit both the scientific community and the wider public.

Locations

Patients applied

0 patients applied

Trial Officials

Alexandre Conte

Study Chair

Paulista U

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Similar Trials