Animal and Plant Proteins and Glucose Metabolism

Launched by UNIVERSITY OF MISSOURI-COLUMBIA · Jun 20, 2019

Keywords

ClinConnect Summary

This clinical trial is studying how different types of protein in our diet—specifically from animals versus plants—affect how our bodies manage blood sugar and insulin, especially for people with metabolic syndrome. Researchers want to see if eating more protein can improve how the liver and muscles respond to insulin and how our bodies process food throughout the day. They will also look at levels of glucose and other substances in the blood that might influence metabolic health.

To join the study, participants need to be aged between 21 and 70, have a body mass index (BMI) between 24.5 and 32.5, and currently eat less protein than recommended. It's important that they have not made significant changes in weight or exercise habits in the last two months and are not on certain medications or diets, like being vegetarian or vegan. Participants will be asked to follow a specific high-protein diet and will have their health closely monitored throughout the trial. This study could help us understand better ways to improve blood sugar management and overall metabolic health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age: ≥21 and ≤70 years;
• • BMI: \>24.5 and \<32.5 kg/m2;
• • habitual protein intake \<0.9 g/kg/day (assessed on 2 weekdays and 2 weekend days by using the HealthWatch 360 app); and
• • weight stable (i.e., ≤3% change) and untrained (≤150 min of structured exercise/week) for at least 2 months before entering the study.
• Exclusion Criteria:
• • prediabetes or type 2 diabetes;
• • evidence of chronic kidney disease by medical history or laboratory tests (glomerular filtration rate \<60 ml/min/1.73 m2 or an albumin to creatinine ratio in urine ≥30 mg/g);
• • vegetarians or vegans;
• • intolerance or allergies to ingredients in the metabolic meal or intervention diet;
• • take dietary supplements (e.g., pre- and probiotics, fiber, fish oil) or medications known to affect our study outcomes;
• • received antibiotic or antifungal treatment (which affect the microbiome and therefore microbial metabolite production) 2 months before entering the study;
• • consume tobacco products or excessive alcohol (women: \>14 drinks/week; men: \>21 drinks/week);
• • evidence of significant organ system dysfunction or diseases (e.g., cirrhosis), and
• • unwilling or unable to provide informed consent.