The Correlation and Intervention of Intestinal Flora and Frailty in the Elderly

Launched by XIJING HOSPITAL · Jun 21, 2019

Keywords

ClinConnect Summary

100 healthy controls, 100 pre-frailty and 100 frailty elderly will be included. the healthy controls will be received no intervention. The pre-frailty will be randomized at a 1：1 ratio to receive prebiotics (inulin) or placebo (maltodextrin) . The degree of improvements and correlation in frailty will be evaluated three months later.Similarly,the frailty also will be randomized at a 1：1 ratio to receive prebiotics (inulin) or placebo (maltodextrin). The degree of improvements and correlation in frailty will be evaluated three months later.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥65 years;
• • Can get up from a chair and walk 6 meters
• • Clearly consciousness, able to read or use words to express and communicate without difficulty
• • Agree and accept the study plan
• Exclusion Criteria:
• • Acute and chronic inflammatory disease of the intestine within 3 months
• • Use of antibiotics, probiotics, prebiotics or synthetics, laxatives or diarrhea medications, proton pump inhibitors or gastric motility drugs within 1 month
• • Dementia
• • mental illness or blindness
• • acute infection
• • cancer