Oral Viscous Budesonide in Anastomotic Stricture After Esophageal Atresia Repair (OVB in EA)

Launched by ST. JUSTINE'S HOSPITAL · Jun 24, 2019

Keywords

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Children aged \> 1 month to 3 years
• • Operated for an esophageal atresia of all types except pure TEF.
• * Presence of an anastomotic stricture defined according to experts recommendations :
• • a relative esophageal narrowing at the level of the anastomosis,
• • demonstrated by a contrast study and/or an endoscopy
• • with significant functional impairment and associated symptoms requiring dilation.
• • Symptoms include: feeding or swallowing difficulties, coughing and choking during feeds, food impaction, regurgitation/vomiting of undigested food, drooling. In very young patients: apnea and food refusal.
• • Receiving an ongoing treatment by PPI 1 to 2 mg/kg die
• • Informed parental consent
• Exclusion Criteria:
• • Known immune deficiency
• • Acute respiratory or intestinal infection
• • Severe respiratory, cardiac or neurological condition precluding OVB or placebo swallowing
• • Child fed exclusively via nasogastric tube or gastrostomy
• • Absence of parental consent