Mandibular Reconstruction With Axially Vascularised Bone Substitutes

Launched by UNIVERSITY OF ALEXANDRIA · Jun 26, 2019

Keywords

ClinConnect Summary

This clinical trial is exploring a new method for reconstructing the lower jaw (mandible) in patients who have lost part of it due to injuries, tumors, or severe infections. The study focuses on using a special technique called axial vascularization, which helps ensure that the new bone substitute receives a good blood supply. This is important because proper blood flow is essential for healing and integrating the new tissue. While this technique has shown promise in other cases, it has not yet been used specifically for the jaw area, making this trial significant.

To be eligible for the trial, participants need to be between 18 and 65 years old and have a specific type of jaw defect that is at least 6 centimeters long. They should also be free of tumors in the affected area. Participants can expect to undergo procedures that utilize this new method of bone reconstruction, and the study team will monitor their progress closely. It's important to know that individuals with certain chronic health conditions or who are outside the age range will not be able to participate. This trial aims to improve the options available for patients needing jaw reconstruction, ultimately enhancing their recovery and quality of life.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients requiring mandibular reconstruction for further dental rehabilitation
• • Mandibular defect (marginal/segmental) equals or more than 6 cm in largest dimension
• • Middle age adult (18-65 years)
• • Radiologically and pathologically documented tumour free mandibular defect
• Exclusion Criteria:
• • Extremes of age (\<18 or \> 65 years)
• • Associated uncontrolled chronic illness (Diabetes mellitus, Hypertension, Rheumatoid arthritis, collagen disease, Chronic obstructive pulmonary disease)
• • Primary reconstruction of a mandibular defect after tumour excision