ESD for Colorectal LSL Using a Selective Strategy - a Prospective Cohort Study

Launched by WESTERN SYDNEY LOCAL HEALTH DISTRICT · Jul 3, 2019

Keywords

ClinConnect Summary

This clinical trial is studying a treatment method called Endoscopic Submucosal Dissection (ESD) for large, flat growths in the colon known as laterally spreading lesions (LSL). These lesions can be over 20mm in size and have a higher risk of developing into cancer. The goal of the study is to better understand how to safely remove these lesions in one piece (called 'en-bloc' resection) to help doctors accurately assess whether cancer is present and potentially avoid more invasive surgeries.

To participate in this trial, patients must be between 65 and 74 years old and have been referred for surgery to remove large LSLs. They should be able to provide informed consent, meaning they understand the trial and agree to take part. However, individuals who have had previous attempts to remove the lesions, those with certain health conditions, or those under 18 years old cannot join. If you participate, you can expect to undergo the ESD procedure and receive careful monitoring to see how effective this approach is in managing these lesions while minimizing the need for more drastic interventions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All patients referred for colorectal resection of large laterally spreading lesions in colon.
• • Can give informed consent to trial participation
• Exclusion Criteria:
• • Previous resection or attempted resection of target adenoma lesion
• • Endoscopic appearance of invasive malignancy
• • Age less than 18 years
• • Pregnancy
• • Active Inflammatory colonic conditions (e.g. inflammatory bowel disease)
• • Use of anticoagulant or antiplatelet agents other than aspirin outside of internationally recognised guidelines
• • American Society of Anesthesiology (ASA) Grade IV-V