Phenotyping Genetic Risk for Type 2 Diabetes

Launched by UNIVERSITY OF PENNSYLVANIA · Jul 16, 2019

Keywords

ClinConnect Summary

This clinical trial is looking at how genetic factors may influence the risk of developing type 2 diabetes. Specifically, the researchers want to see if people who have a high genetic risk for this condition also have problems with how their body processes sugar and insulin, compared to those with a lower genetic risk. By understanding these differences, the study aims to gain insight into diabetes risk and potentially improve prevention strategies.

To participate in this study, you need to be between the ages of 10 and 70 and have previously agreed to be contacted for research through the UPenn Biobank. Adults should have a body mass index (BMI) of 25 or higher, while children and adolescents should be at or above the 85th percentile for BMI. However, there are certain conditions that would exclude you from participating, such as having a prior diagnosis of any type of diabetes, taking specific medications that affect blood sugar levels, or having certain health issues. If you qualify and choose to join, you can expect to undergo tests to evaluate your glucose and insulin responses as part of the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 10-70 years
• • Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research.
• • Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher
• Exclusion Criteria:
• • prior diagnosis of type 1, type 2, or secondary diabetes
• • use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication
• • acute illness that may impact insulin and glucose dynamics
• • pregnancy
• • hypothalamic obesity or related genetic disorder of metabolism
• • recent systemic chemotherapy use
• • gastrointestinal impairment or surgery that may impact absorption
• • anemia
• • major organ system illness or any underlying condition requiring regular medication or treatment that could make implementation of the protocol or interpretation of the study results difficult
• • inability to comply with study protocol