Cannabidiol, Morphine, Pain

Launched by WAYNE STATE UNIVERSITY · Jul 17, 2019

Keywords

ClinConnect Summary

This clinical trial is studying how cannabidiol (CBD), a compound found in marijuana, interacts with morphine to affect pain sensitivity. The researchers want to understand if combining these two substances can help manage chronic pain more effectively. The trial is currently recruiting participants aged 65 to 88, and both men and women are welcome to join.

To participate, you need to have smoked either cigarettes or marijuana and have taken opioids (like morphine) at least three times in your life. You should be in good health, as certain medical conditions will exclude you from the study. Participants will go through a thorough health assessment, including medical history, physical exams, and lab tests, to ensure they are suitable for the trial. If you decide to join, you’ll be contributing to important research that could improve pain management for many people.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants must report having smoked a cigarette (nicotine or marijuana) AND having taken an opioid on 3 or more occasions in their lifetime.
• • Participants must be in good health to participate; those with certain contraindications will be excluded.
• • All participants will undergo psychiatric evaluation and will be asked to report their substance use history by interview and structured questionnaire methods.
• • Participants will undergo medical evaluations using medical history, physical exam, standard lab tests (complete blood chemistry, urinalysis, urine pregnancy test for females), and 12-lead ECG.
• Exclusion Criteria:
• • Serious psychiatric illness (e.g. psychotic or bipolar disorder, recent suicide attempts; severe depression)
• • Substance Use Disorders other than Nicotine Use Disorder and Mild Cannabis Use Disorder
• • Neurological diseases; cardiovascular problems (e.g. systolic BP \>140 or \<95 mmHg, diastolic BP \>90 mmHg, abnormal ECG); pulmonary diseases; systemic diseases (e.g. liver, renal, inflammatory)
• • Cognitive impairment (\<80 IQ)
• • Past-month medications that increase study risk
• • Women who are pregnant (urine HCG), lactating (self-report), or if heterosexually active and not using (self-report) medically approved birth control (oral or depot contraception, IUD, condom/foam, sterilization, tubal ligation)
• • Individuals unable to give informed consent will be excluded.