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Search / Trial NCT04040920

Ozone Application Before Fissure Sealants

Launched by IRCCS BURLO GAROFOLO · Jul 30, 2019

Trial Information

Current as of July 22, 2025

Recruiting

Keywords

Ozone Pits And Fissures Sealants Prevention

ClinConnect Summary

This clinical trial is looking at whether applying ozone to teeth before placing sealants can help those sealants last longer. Sealants are protective coatings placed on the chewing surfaces of back teeth, which can help prevent cavities, especially in the little grooves and pits where decay often starts. Ozone is being studied because it can kill bacteria and help strengthen the tooth enamel, which might make the sealants more effective.

To participate in this study, you need to have a first or second back tooth that can be sealed and be in good general health. It’s important that the tooth can be properly isolated during the procedure, and there shouldn't be any visible stains or health conditions like severe asthma or certain neurological disorders. If you join the study, you can expect to receive ozone treatment on your tooth before the sealant is applied, and your progress will be monitored to see how well the sealant works over time. This trial is currently recruiting participants of all genders aged between 2 and 58 years.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • first or second secondary molars to be sealed
  • possibility to isolate with rubber dam both the teeth involved
  • no clear signs of pigmentations
  • good general health
  • Exclusion Criteria:
  • latex allergy
  • epilepsy or other severe neurological pathologies
  • psychiatric disease
  • excessive sensibility to electrical current
  • severe asthma
  • enamel disorders, such as amelogenesis imperfect, white spots, fluorosis or Molar Incisors Hypomineralization

About Irccs Burlo Garofolo

IRCCS Burlo Garofolo is a prestigious research institute located in Trieste, Italy, dedicated to advancing pediatric healthcare through innovative clinical research. As a recognized IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), it focuses on a wide range of pediatric diseases, emphasizing the integration of clinical care and scientific research to improve patient outcomes. The institute collaborates with various national and international partners, fostering an environment of rigorous scientific inquiry and excellence in medical practice. Its commitment to ethical standards and patient safety ensures that all clinical trials conducted under its auspices contribute meaningful advancements in pediatric medicine.

Locations

Trieste, , Italy

Patients applied

0 patients applied

Trial Officials

Milena Cadenaro, DDS,MSc,PhD

Study Chair

IRCCS Burlo Garofolo

Maddalena Chermetz, DDS,MSc

Principal Investigator

IRCCS Burlo Garofolo

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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