Genetic Causes of Discrepant Clinic in Monogenic Twins
Launched by UNIVERSITY HOSPITAL TUEBINGEN · Aug 2, 2019
Trial Information
Current as of July 24, 2025
Recruiting
Keywords
ClinConnect Summary
The DISCO-TWIN study is looking into the genetic reasons why one twin may be healthy while the other has a rare disease that doctors have struggled to diagnose. Researchers will examine pairs of identical twins, where one twin is affected by an unclear condition, to explore their genetic information. By using advanced technology and sharing findings with other medical experts, the study aims to improve understanding and diagnosis of these mysterious health issues.
To participate in this study, you must be part of an identical twin pair where one twin is healthy, and the other has a disease that doctors cannot clearly identify. Both twins need to agree to take part in the study, and they should have no obvious differences in their health that would prevent participation. If you join the study, you can expect to contribute to important research that could help identify genetic causes of diseases, potentially benefiting not just your family but others with similar health challenges.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Twin pair monozygotic clinically (phenotypic) discordant twins
- • Unclear diagnosis
- • Suspected (mono-)genetic cause of the disease in one twin
- Exclusion Criteria:
- • Missing informed consent of both twin/ legal representative
- • No distinct phenotype
About University Hospital Tuebingen
University Hospital Tübingen is a leading academic medical institution in Germany, renowned for its commitment to advancing healthcare through innovative research and clinical excellence. As a prominent sponsor of clinical trials, the hospital leverages its multidisciplinary expertise and cutting-edge facilities to develop new therapeutic strategies and improve patient outcomes. With a strong focus on translational medicine, University Hospital Tübingen collaborates with various stakeholders, including pharmaceutical companies and research organizations, to facilitate the efficient and ethical conduct of trials across a wide range of medical disciplines. Their dedication to patient-centered research and rigorous scientific standards positions them at the forefront of medical advancements.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Tübingen, , Germany
Patients applied
Trial Officials
Jeannette Hübener-Schmid, Dr.
Principal Investigator
University Hospital Tübingen
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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