Pilot Study to Evaluate the Role of EBUS in the Diagnosis of Acute PE in Critically Ill Patients

Launched by UNIVERSITY OF CALIFORNIA, LOS ANGELES · Aug 4, 2019

Keywords

ClinConnect Summary

This is a single center, pilot study to evaluate critically ill patients diagnosed with acute pulmonary embolism using endobronchial ultrasound (EBUS). The investigators anticipate to enroll 20 subjects at Ronald Reagan UCLA Medical Center and UCLA Medical Center, Santa Monica. The enrolled subjects will be imaged using the flexible bronchoscopy with EBUS.

After informed consent is obtained, the following procedure will be performed:

An Olympus EBUS bronchoscope will be used for all endobronchial ultrasound examinations. This scope has a 6.9 mm outer diameter, a 2.7 mm working channel and...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient ≥ 18 years of age.
• • The patient or patient's surrogate must understand and sign informed consent form (ICF).
• • Intubated patients in the intensive care unit (ICU) where there is a clinical concern for acute pulmonary embolism or a confirmed diagnosis for acute pulmonary embolism.
• Exclusion Criteria:
• • Patient does not meet the requirements to undergo clinical bronchoscopy, as determined by the treating physician.
• • Endotracheal tube size less than 8.0 mm.
• • Contraindications to lidocaine.
• Pulmonary Vascular Mapping Substudy:
• Enrollment for the pulmonary vascular mapping substudy will be based on the following inclusion and exclusion criteria:
• Inclusion criteria:
• • Patient ≥ 18 years of age.
• • The patient or patient's surrogate must understand and sign informed consent form (ICF).
• • Intubated patients undergoing clinical bronchoscopy, as determined by the treating physician.
• Exclusion criteria:
• • Patient does not meet the requirements to undergo clinical bronchoscopy, as determined by the treating physician.
• • Endotracheal tube size less than 8.0 mm.
• • Contraindications to lidocaine.
• Retrospective Chart Review:
• • Of the 60 total subjects enrolled in the study, media including images and videos that are previously recorded for 20 patients who underwent a clinical bronchoscopy with EBUS as a part of their standard of care will also be available to our research team without consent from the patient to help supplement the data we obtain from the 20 subjects that are enrolled in the pulmonary vascular mapping substudy.