Therapeutic Abstention and Surveillance of Intra-epithelial Histological Lesions of High Grade Cervical CIN2 (Cervical Intraepithelial Neoplasia Grade 2). SUIVICIN

Launched by UNIVERSITY HOSPITAL, BORDEAUX · Aug 13, 2019

Keywords

ClinConnect Summary

The SUIVICIN trial is a study looking at how often certain cervical lesions, called CIN2, go away on their own without treatment over a two-year period. CIN2 is a condition linked to HPV infection, which can lead to cervical cancer if not monitored. The trial focuses on women aged 18 to 39 who have been diagnosed with CIN2 through a biopsy. Instead of undergoing standard treatment, these women will be closely observed to see if their condition improves naturally.

To participate in this trial, women must be between 18 and 39 years old, have confirmed CIN2, and meet certain health criteria. They should not be pregnant or have a history of specific health issues that could complicate the study. Participants can expect regular follow-ups to monitor their condition during the study period. This research could provide valuable insights into whether some women with CIN2 can avoid treatment and still have a good outcome.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • CIN2 confirmed by biopsy, age between 18 and 39 years,
• • satisfactory colposcopy identifying the junction and the lesion,
• • affiliated person or beneficiary of a social security scheme,
• • having given their oral agreement and authorization to the processing of their data.
• Exclusion Criteria:
• • Pregnancy in progress,
• • history of conization,
• • atypical or atypical glandular cells or cancer incidentally discovered during smear,
• • prophylactic vaccination against HPV,
• • active systemic infection requiring treatment, history of HIV infection, congenital or acquired immunodepression,
• • long-term treatment with corticosteroids or immunosuppressants, placement under safeguard of justice,
• • non-compliance with protocol requirements, in particular a supposed lack of compliance with long-term follow-up