Functionality of Endogenous Biological Clock in Sepsis

Launched by UNIVERSITY OF ATHENS · Aug 17, 2019

Keywords

ClinConnect Summary

This clinical trial, titled "Functionality of Endogenous Biological Clock in Sepsis," is investigating how sepsis, a serious infection that can affect the body’s ability to function, disrupts the body's natural daily rhythms, known as circadian rhythms. The researchers want to find out how this disruption affects the immune system and overall health compared to people who do not have sepsis. Understanding these changes could help improve care for patients with sepsis.

The trial is open to adults aged 18 and older, including both men and women. To participate, individuals can either be healthy without any other health issues, be patients with conditions similar to those with sepsis but without the infection, or be patients currently experiencing sepsis. Participants will be asked to provide consent and may undergo various assessments to help researchers learn more about the connection between circadian rhythms and sepsis. It’s important to note that certain health conditions, like active cancer or severe respiratory issues, may exclude someone from participating in this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults (age ≥18 years)
• • Written informed consent
• • Male or female gender
• * Οne of the following cases:
• • Healthy controls without comorbidities OR
• • Patients without sepsis or infection , with identical Charlson Comorbidity Index and same mental status with the septic patients OR
• • Patients with sepsis
• Exclusion Criteria:
• • Failure to obtain written informed consent
• • Age \<18 years
• • Pregnancy or breastfeeding
• • Solid tumor or hematologic malignancy
• • Asthma
• • Neurodegenerative disease
• • Traumatic brain injury
• • Confirmed depression
• • Autoimmune disorders
• • Special categories following unfixed or varying routine schedules (e.g. travels overseas or even short distances, if frequent/jet lag/on-call duties/nightshifts with regard to doctors,security guards,singers)
• • Per os or iv corticosteroids daily intake of dose at least
• • Corticosteroid oral or intravenous intake of at least 0.4 mg/kg of equivalent prednisone daily over the last 15 days