MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets

Launched by UNC LINEBERGER COMPREHENSIVE CANCER CENTER · Aug 27, 2019

Keywords

ClinConnect Summary

This clinical trial is studying how radiation therapy, specifically Stereotactic Radiosurgery (SRS), affects brain function and cognitive abilities in adults who have newly diagnosed brain metastases, which are cancer cells that have spread to the brain from other parts of the body. Researchers want to understand the changes in brain tissue that occur after treatment and how these changes may lead to problems with thinking and memory. By identifying these effects, the study aims to improve care for patients undergoing treatment for brain metastases.

To participate in this trial, you need to be at least 18 years old and have a confirmed diagnosis of cancer with brain metastases that are being treated with SRS. You should also expect to live at least another year. Participants will be closely monitored throughout the study, which may involve regular brain imaging and assessments of cognitive function. It’s important to note that people who have had previous radiation to the brain, other serious health conditions, or certain neurological disorders are not eligible for this study. If you or a loved one meet the criteria and are interested in participating, this trial could help advance our understanding of how to better support patients facing these challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Histologic diagnosis of cancer
• • Newly diagnosed brain metastasis being treated with SRS. Any extent of cranial disease permitted. Subsequent courses of SRS while on study permitted when clinically indicated.
• • Patients are permitted to have undergone craniotomy and resection of metastasis/metastases if at least 1 other intact metastasis planned for definitive SRS is present. Receiving or previously received systemic therapy also permitted.
• • Anticipated life expectancy at least 1 year
• • Age ≥ 18 years
• • Ability to read and comprehend written English and follow instructions in English
• • Ability to provide informed consent
• Exclusion Criteria:
• • Previous radiation to the brain or head
• • Previous malignancy - other than non-melanomatous skin cancer or cervical carcinoma in situ - and not disease-free for at least 3 years
• • Previous severe head or brain injury
• • History of a neurological disorder such as Epilepsy, Parkinson's, Alzheimer's, or Dementia
• • Prisoners