68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors.

Launched by WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY · Sep 6, 2019

Keywords

ClinConnect Summary

This clinical trial is studying a special imaging test called 68-Ga DOTATATE PET/MRI to help doctors diagnose and manage certain types of brain tumors known to have somatostatin receptors, which are proteins that can be found in these tumors. The main focus is on a type of tumor called meningioma, but the study also includes other brain tumors like esthesioneuroblastoma, hemangioblastoma, medulloblastoma, paraganglioma, and pituitary adenoma. Researchers want to see if this imaging test can help tell the difference between a tumor coming back after treatment and changes in the brain that happen after surgery or radiation.

To participate in this trial, individuals must be at least 18 years old and have been diagnosed with meningioma or other related tumors that show signs of coming back based on regular MRI scans. Participants can expect to undergo the 68-Ga DOTATATE PET/MRI test, which may help identify any remaining tumor after surgery and check for other lesions that might not show up on standard MRI. It’s important to know that people with certain allergies to the contrast agent used in the imaging or who are pregnant cannot participate. The trial is currently recruiting participants, and it aims to gather important information to improve the diagnosis and treatment of these types of tumors.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ≥ 18 years of age
• • Diagnosis of meningioma based on pathology reports and suspected recurrence or residual disease based on standard-of-care MRI
• • Additionally, patients with other somatostatin receptor 2 positive brain tumors, including esthesioneuroblastoma, hemangioblastoma, medulloblastoma, paraganglioma, pituitary adenoma, and SSTR-positive systemic cancers metastatic to the brain will be considered for the purposes of obtaining feasibility data
• • As the investigator's institution, PET/MRI scanner utilizes a 3 Tesla (T) magnet, patients who may be ineligible to undergo 3T MRI but may undergo 1.5 Tesla (T) MRI, will undergo a 1.5T MRI as per clinical standard-of-care and a Ga68-DOTATATE PET/CT with the PET portion to be fused with the 1.5T MRI utilizing fusion software.
• Exclusion Criteria:
• • Contraindications to gadolinium-based contrast agent
• • History of allergic reaction to Gallium-68-DOTATATE
• • Pregnancy