CREDE Study: Intraoperative Crede Manoeuver Compared to Preoperative Prolapse Reduction Stress Test to Predict Postoperative de Novo Stress Urinary Incontinence (PONSUI) at the Time of Pelvic Organ Prolapse (POP) Surgery

Launched by MCGILL UNIVERSITY HEALTH CENTRE/RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE · Sep 11, 2019

Keywords

ClinConnect Summary

The CREDE Study is a clinical trial designed to find the best way to predict and prevent a condition called de Novo Stress Urinary Incontinence (PONSUI) in women undergoing surgery for pelvic organ prolapse (POP). In this study, researchers are comparing two methods: one that happens during the surgery (the intraoperative Crede maneuver) and another that takes place before the surgery (the preoperative cough stress test). The goal is to see which method better helps to identify women at risk of developing urinary incontinence after their surgery, and how this affects their quality of life.

To participate in the CREDE Study, women must be between the ages of 65 and 74 and have a specific type of pelvic organ prolapse that needs surgical treatment. Certain women may not be eligible, such as those who have a history of stress urinary incontinence, have had previous surgeries for incontinence, or are currently pregnant. If you join the study, you will undergo either the intraoperative or the preoperative test, and then you will be followed up for six months to see how you are doing. This trial is important because it aims to gather information that will help improve future treatments for women facing these issues.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Anterior, uterine or apical prolapse with a POP-Q stage II or more requiring surgical correction
• Exclusion Criteria:
• • Stress urinary incontinence (SUI) on history
• • Previous anti-incontinence surgery
• • Pregnancy
• • Prior urethral repair surgery (diverticulum, fistula)
• • Women who do not speak or read English or French
• • Isolated posterior compartment prolapse
• • Geographic location preventing women to come to 6 week and 6 month appointments