Optimisation of Radiotherapy in Rectal Cancer (ORREC)
Launched by UNIVERSITY OF MANCHESTER · Sep 12, 2019
Trial Information
Current as of July 07, 2025
Unknown status
Keywords
ClinConnect Summary
The treatment of locally advanced rectal cancer is primarily radiotherapy (+/- chemotherapy) followed by surgery. The reason for radiotherapy is to reduce the risk of recurrence after surgery or to shrink the tumour first so that when surgery is done all the cancer will be successfully removed otherwise some will be left behind to grow. More than 80% of patients require a stoma after their surgery, some get reversed by two years after surgery but a third has it lifelong. About 15% of patients after radiotherapy have no disease left (clinical complete response) and can be monitored closely a...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Histologically confirmed rectal adenocarcinoma.
- • Received pelvic radiotherapy (+/- chemotherapy) as neo-adjuvant treatment
- • Age 18 and above
- Exclusion Criteria:
- • Other rectal pathologies.
- • Patients less than 18yrs at diagnosis.
About University Of Manchester
The University of Manchester is a leading research institution known for its commitment to advancing healthcare through innovative clinical trials. With a strong emphasis on multidisciplinary collaboration, the university leverages its extensive expertise in biomedical research and clinical practice to develop and evaluate new therapies and interventions. The institution is dedicated to improving patient outcomes and public health by conducting rigorous, ethically sound trials that adhere to the highest standards of scientific integrity. Through its state-of-the-art facilities and a robust network of healthcare partnerships, the University of Manchester actively contributes to the global body of medical knowledge and the translation of research findings into clinical applications.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Manchester, England, United Kingdom
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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